Pyxis Oncology, Inc. - Common Stock, par value $0.001 per share (PYXS) Institutional Ownership

13F Institutional Holders and Ownership History from Q4 2021 to Q4 2025

Type / Class
Equity / Common Stock, par value $0.001 per share
Symbol
PYXS on Nasdaq
Shares outstanding
62,933,385
Price per share
$1.15
All holders as of 30 Sep 2025
Q3 2025
Total 13F shares
26,829,595
Total reported value
$59,741,454
% of total 13F portfolios
0%
Share change
-628,053
Value change
+$123,859
Number of holders
73
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Pyxis Oncology, Inc. - Common Stock, par value $0.001 per share (PYXS) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
Sullivan Lara 11% +9.1% $7,241,287 +$881,576 7,543,007 +14% Lara Sullivan, M.D. 31 Mar 2025
GordonMD Global Investments LP 6.2% $5,330,289 3,834,740 GordonMD Global Investments LP 14 Jul 2025
INTEGRATED CORE STRATEGIES (US) LLC 4% -26% $2,388,556 -$645,178 2,488,079 -21% Millennium Management LLC 31 Mar 2025
BlackRock, Inc. 1.5% -68% $1,065,826 -$2,779,936 926,805 -72% BlackRock, Inc. 30 Jun 2025
MILLENNIUM MANAGEMENT LLC 1.3% -73% $1,497,185 -$4,985,888 818,134 -77% Millennium Management LLC 30 Sep 2025
Ridgeback Capital Investments L.P. 0.6% $344,862 359,231 Ridgeback Capital Investments L.P. 31 Dec 2024

As of 30 Sep 2025, 73 institutional investors reported holding 26,829,595 shares of Pyxis Oncology, Inc. - Common Stock, par value $0.001 per share (PYXS). This represents 43% of the company’s total 62,933,385 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Pyxis Oncology, Inc. - Common Stock, par value $0.001 per share (PYXS) together control 40% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
Pfizer Inc 11% 7,032,770 0% 3.6% $15,612,750
Laurion Capital Management LP 5.8% 3,625,974 0% 1.1% $8,049,662
TANG CAPITAL MANAGEMENT LLC 4% 2,500,000 0% 0.21% $5,550,000
VANGUARD GROUP INC 3.4% 2,163,962 +0.68% 0% $4,803,996
PERCEPTIVE ADVISORS LLC 1.9% 1,178,307 0.08% $2,615,842
Palo Alto Investors LP 1.6% 1,037,421 0% 0.43% $2,303,075
MILLENNIUM MANAGEMENT LLC 1.3% 815,331 -77% 0% $1,810,035
STEMPOINT CAPITAL LP 1.1% 689,538 0.31% $1,530,774
BlackRock, Inc. 1.1% 683,702 -26% 0% $1,517,818
BANK OF AMERICA CORP /DE/ 0.98% 615,922 +2691% 0% $1,367,347
RENAISSANCE TECHNOLOGIES LLC 0.92% 576,336 +38% 0% $1,279,466
GEODE CAPITAL MANAGEMENT, LLC 0.87% 544,508 +6.6% 0% $1,209,225
683 Capital Management, LLC 0.83% 525,000 -3.7% 0.11% $1,165,500
Longaeva Partners L.P. 0.8% 503,214 0.24% $1,117,135
Driehaus Capital Management LLC 0.67% 418,632 0.01% $929,363
UBS Group AG 0.59% 373,727 -5.6% 0% $829,674
CITADEL ADVISORS LLC 0.54% 337,359 0% $748,937
Decheng Capital LLC 0.52% 326,810 0% 0.13% $725,518
JANE STREET GROUP, LLC 0.48% 303,700 -9.6% 0% $674,214
SCHULHOFF & CO INC 0.44% 275,000 0% 0.26% $610,500
STATE STREET CORP 0.32% 202,055 +8.6% 0% $448,562
Bank of New York Mellon Corp 0.26% 165,044 0% 0% $366,397
PIER 88 INVESTMENT PARTNERS LLC 0.24% 151,730 -59% 0.06% $336,841
DIADEMA PARTNERS LP 0.24% 150,000 0.23% $333,000
SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.22% 137,531 +20% 0% $305,319

Institutional Holders of Pyxis Oncology, Inc. - Common Stock, par value $0.001 per share (PYXS) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 28,306 $32,552 +$31,447 $1.15 2
2025 Q3 26,829,595 $59,741,454 +$123,859 $2.22 73
2025 Q2 27,457,764 $30,197,446 -$2,879,025 $1.10 74
2025 Q1 30,249,132 $29,641,065 -$2,654,674 $0.98 87
2024 Q4 31,532,130 $49,192,598 -$20,823,300 $1.56 96
2024 Q3 27,885,908 $103,378,351 -$988,134 $3.67 91
2024 Q2 28,117,599 $93,074,888 +$16,220,645 $3.31 79
2024 Q1 22,927,678 $97,671,130 +$61,670,063 $4.26 69
2023 Q4 8,794,942 $15,829,945 +$878,877 $1.80 49
2023 Q3 7,757,315 $15,436,473 -$3,492,579 $1.99 49
2023 Q2 9,605,170 $24,586,580 -$3,314,110 $2.56 46
2023 Q1 10,344,616 $41,481,052 -$20,572,283 $4.01 45
2022 Q4 19,762,209 $26,479,807 -$1,331,681 $1.34 31
2022 Q3 19,443,728 $38,301,000 -$1,468,433 $1.97 35
2022 Q2 20,034,321 $47,682,000 -$655,397 $2.38 37
2022 Q1 18,945,864 $76,066,000 -$5,560,293 $4.04 43
2021 Q4 18,338,628 $199,903,000 +$199,792,802 $10.97 51