| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Medicxi IV LP | 16.9% | $19M | 22.4M | Medicxi IV GP Limited | Dec 27, 2024 | |||
| Deep Track Capital, LP | 9.87% | $12M | 14.1M | Deep Track Capital, LP | Dec 23, 2024 | |||
| Redmile Group, LLC | 9.9% | $11.8M | 13.9M | Redmile Group, LLC | Dec 31, 2024 | |||
| TCG Crossover GP II, LLC | 9.99% | $11.2M | 13.2M | TCG Crossover GP II, LLC | Dec 27, 2024 | |||
| Foresite Capital Fund VI LP | 9.3% | $10.6M | 12.5M | Foresite Capital Fund VI, L.P. | Dec 23, 2024 | |||
| RTW INVESTMENTS, LP | 8.9% | $10M | 11.8M | RTW Investments, LP | Mar 31, 2025 | |||
| VANGUARD GROUP INC | 6.27% | +203% | $7.04M | $4.54M | 8.28M | +182% | The Vanguard Group | Mar 31, 2025 |
| PERCEPTIVE ADVISORS LLC | 4.5% | $5M | 5.88M | Perceptive Advisors LLC | Dec 31, 2024 | |||
| BlackRock, Inc. | 1.7% | $1.96M | 2.31M | BlackRock, Inc. | Mar 31, 2025 | |||
| COLUMN GROUP II, LP | 4.9% | $1.36M | 1.6M | Peter Svennilson | Dec 23, 2024 | |||
| ORBIMED ADVISORS LLC | 6.6% | -33% | $28M | -$311M | 1.09M | -91.7% | ORBIMED ADVISORS LLC | Sep 30, 2025 |
| FMR LLC | 0.4% | $408K | 481K | FMR LLC | Jan 31, 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 2.97M | $76.7M | +$42.1M | $25.79 | 3 |
| 2025 Q2 | 1.34M | $10.7M | -$159M | $8.00 | 2 |
| 2025 Q1 | 131M | $160M | +$4.42M | $1.22 | 89 |
| 2024 Q4 | 127M | $199M | +$131M | $1.58 | 89 |
| 2024 Q3 | 29.8M | $59.9M | -$5.4M | $2.01 | 93 |
| 2024 Q2 | 31.8M | $97M | -$17.6M | $3.05 | 104 |
| 2024 Q1 | 17.7M | $159M | -$170M | $8.98 | 67 |
| 2023 Q4 | 63.8K | $1.59M | -$915K | $24.85 | 1 |
| 2023 Q3 | 34.8M | $578M | +$6.72M | $16.62 | 98 |
| 2023 Q2 | 34.1M | $637M | +$14.4M | $18.70 | 98 |
| 2023 Q1 | 33.3M | $611M | +$19.8M | $18.35 | 104 |
| 2022 Q4 | 32.1M | $635M | +$67.4M | $19.80 | 92 |
| 2022 Q3 | 29.2M | $702M | -$15.8M | $24.06 | 91 |
| 2022 Q2 | 28.7M | $523M | +$30.2M | $18.25 | 83 |
| 2022 Q1 | 28M | $615M | -$10.2M | $21.99 | 79 |
| 2021 Q4 | 27.7M | $1.02B | +$58.6M | $36.73 | 99 |
| 2021 Q3 | 26.2M | $774M | -$11.9M | $31.05 | 104 |
| 2021 Q2 | 26.6M | $804M | +$200M | $31.79 | 107 |
| 2021 Q1 | 21.1M | $468M | +$14.6M | $22.20 | 77 |
| 2020 Q4 | 19.7M | $389M | -$1.78M | $19.75 | 78 |
| 2020 Q3 | 16.8M | $542M | +$65.3M | $32.20 | 66 |
| 2020 Q2 | 14.8M | $430M | +$93.9M | $29.02 | 52 |
| 2020 Q1 | 11.7M | $248M | +$53.9M | $21.27 | 36 |
| 2019 Q4 | 9.14M | $252M | +$252M | $27.61 | 26 |