| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Commodore Capital LP | 9.9% | +26% | $88,740,000 | +$19,053,000 | 17,000,000 | +27% | Commodore Capital LP | 30 Sep 2025 |
| Point72 Asset Management, L.P. | 7.8% | +35% | $47,463,335 | +$13,242,749 | 13,445,704 | +39% | Point72 Asset Management, L.P. | 30 Jun 2025 |
| BlackRock, Inc. | 6.1% | -30% | $24,945,389 | -$10,566,325 | 10,308,012 | -30% | BlackRock, Inc. | 31 Mar 2025 |
| VANGUARD GROUP INC | 5.5% | -24% | $27,670,560 | -$8,040,429 | 9,379,851 | -23% | The Vanguard Group | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD | 16% | 27,904,963 | 0% | 1.1% | $145,663,907 |
| Commodore Capital LP | 9.9% | 17,000,000 | +27% | 4.3% | $88,740,000 |
| Point72 Asset Management, L.P. | 8.6% | 14,773,676 | +9.9% | 0.17% | $77,118,589 |
| BlackRock, Inc. | 8% | 13,759,382 | -1.4% | 0% | $71,823,974 |
| Casdin Capital, LLC | 6.6% | 11,341,381 | -0.5% | 4.9% | $59,202,009 |
| VANGUARD GROUP INC | 5.5% | 9,395,744 | +0.17% | 0% | $49,045,785 |
| Bellevue Group AG | 4.9% | 8,345,610 | +1.4% | 0.91% | $43,564,084 |
| TANG CAPITAL MANAGEMENT LLC | 4.7% | 8,068,058 | 0% | 1.6% | $42,115,263 |
| STATE STREET CORP | 3% | 5,065,990 | -2.6% | 0% | $26,444,468 |
| Nextech Invest, Ltd. | 2.2% | 3,846,409 | 0% | 3.1% | $20,078,255 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.8% | 3,054,586 | -5.4% | 0% | $15,947,600 |
| Kynam Capital Management, LP | 1.7% | 2,887,014 | 0% | 1.1% | $15,070,213 |
| DIMENSIONAL FUND ADVISORS LP | 1.4% | 2,482,950 | -11% | 0% | $12,960,818 |
| MPM BIOIMPACT LLC | 1.3% | 2,282,680 | 0% | 2% | $11,915,590 |
| GOLDMAN SACHS GROUP INC | 1.1% | 1,868,871 | -3.4% | 0% | $9,755,506 |
| TCG Crossover Management, LLC | 1.1% | 1,810,351 | 0.46% | $9,450,032 | |
| MORGAN STANLEY | 1% | 1,764,096 | +24% | 0% | $9,208,581 |
| Alphabet Inc. | 0.91% | 1,568,753 | 0% | 0.34% | $8,188,891 |
| AQR CAPITAL MANAGEMENT LLC | 0.76% | 1,301,036 | +20% | 0% | $6,791,407 |
| BANK OF AMERICA CORP /DE/ | 0.7% | 1,195,843 | -9.4% | 0% | $6,242,302 |
| Balyasny Asset Management L.P. | 0.68% | 1,174,971 | 0.01% | $6,133,349 | |
| NORTHERN TRUST CORP | 0.68% | 1,165,434 | +0.29% | 0% | $6,083,565 |
| BAKER BROS. ADVISORS LP | 0.68% | 1,160,117 | 0% | 0.04% | $6,055,811 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0.66% | 1,137,681 | -60% | 0% | $5,940,000 |
| TWO SIGMA ADVISERS, LP | 0.65% | 1,124,300 | -1.4% | 0.01% | $5,868,846 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 683,885 | $5,771,622 | +$1,650,890 | 846.02% | 6 |
| 2025 Q3 | 166,222,637 | $867,515,589 | -$18,690,096 | 522% | 196 |
| 2025 Q2 | 170,987,354 | $591,897,333 | +$36,190,049 | 346% | 204 |
| 2025 Q1 | 162,665,545 | $426,190,838 | -$16,276,175 | 262% | 205 |
| 2024 Q4 | 163,887,291 | $675,285,833 | -$17,893,472 | 412% | 196 |
| 2024 Q3 | 157,497,497 | $1,114,779,863 | +$213,149,603 | 708% | 192 |
| 2024 Q2 | 126,709,981 | $826,133,526 | -$18,822,117 | 652% | 171 |
| 2024 Q1 | 128,825,720 | $1,069,253,636 | -$15,181,619 | 830% | 180 |
| 2023 Q4 | 60,647 | $675,115 | -$1,942,317 | 1,117% | 2 |
| 2023 Q3 | 128,926,582 | $1,084,260,246 | -$1,936,952 | 841% | 167 |
| 2023 Q2 | 127,647,902 | $1,603,274,089 | -$46,626,842 | 1,256% | 157 |
| 2023 Q1 | 130,754,404 | $2,151,756,038 | +$54,363,585 | 1,647% | 151 |
| 2022 Q4 | 127,989,516 | $1,912,134,724 | +$47,798,662 | 1,494% | 158 |
| 2022 Q3 | 123,222,908 | $2,756,605,792 | +$23,685,402 | 2,237% | 149 |
| 2022 Q2 | 120,556,159 | $2,019,325,029 | +$125,491,185 | 1,675% | 133 |
| 2022 Q1 | 112,991,648 | $3,381,093,020 | +$65,326,181 | 2,993% | 130 |
| 2021 Q4 | 110,429,984 | $3,390,723,363 | +$589,807,191 | 3,071% | 126 |
| 2021 Q3 | 91,192,604 | $2,876,445,823 | +$72,474,589 | 3,153% | 130 |
| 2021 Q2 | 88,595,794 | $3,241,644,463 | +$135,264,224 | 3,659% | 121 |
| 2021 Q1 | 85,468,376 | $2,954,670,320 | -$171,128,078 | 3,457% | 132 |
| 2020 Q4 | 87,273,471 | $3,627,103,378 | -$126,698,431 | 4,156% | 111 |
| 2020 Q3 | 84,642,724 | $3,601,765,710 | +$3,601,765,728 | 4,259% | 93 |