| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Teoxane SA | 6.2% | 0% | $32,335,404 | 6,550,800 | 0% | Teoxane SA | 30 Jan 2025 | |
| FRANKLIN RESOURCES INC | 4.6% | $23,617,550 | 4,784,658 | Franklin Resources, Inc. | 30 Sep 2024 | |||
| Palo Alto Investors LP | 1.5% | $7,955,942 | 1,611,787 | Patrick Lee, MD | 30 Sep 2024 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q2 | 0 | $0 | -$425,554 | 0 | |
| 2025 Q1 | 86,100 | $425,000 | -$245,915,234 | 493.61% | 1 |
| 2024 Q4 | 81,615,726 | $248,111,500 | -$34,278,677 | 304% | 169 |
| 2024 Q3 | 82,514,296 | $428,141,597 | +$73,554,744 | 519% | 203 |
| 2024 Q2 | 81,380,096 | $209,199,026 | -$16,428,979 | 257% | 172 |
| 2024 Q1 | 83,044,426 | $408,576,667 | +$33,183,947 | 492% | 182 |
| 2023 Q4 | 34,201 | $300,627 | -$201,855 | 879% | 1 |
| 2023 Q3 | 77,685,888 | $891,079,390 | -$145,567,704 | 1,147% | 181 |
| 2023 Q2 | 81,597,941 | $2,065,272,770 | +$115,072,091 | 2,531% | 210 |
| 2023 Q1 | 76,516,583 | $2,464,233,486 | +$117,644,613 | 3,221% | 215 |
| 2022 Q4 | 73,748,021 | $1,361,391,547 | +$100,535,684 | 1,846% | 186 |
| 2022 Q3 | 67,536,506 | $1,821,529,107 | +$324,818,754 | 2,699.99% | 175 |
| 2022 Q2 | 55,780,275 | $770,923,957 | +$8,673,737 | 1,382% | 152 |
| 2022 Q1 | 54,399,919 | $1,060,603,136 | +$29,983,679 | 1,950% | 146 |
| 2021 Q4 | 52,490,585 | $856,706,987 | -$86,379,330 | 1,632% | 139 |
| 2021 Q3 | 54,826,840 | $1,527,481,962 | +$20,185,748 | 2,786.01% | 153 |
| 2021 Q2 | 53,794,598 | $1,592,231,549 | -$21,386,577 | 2,964% | 156 |
| 2021 Q1 | 54,581,540 | $1,525,520,506 | +$56,425,874 | 2,794.99% | 145 |
| 2020 Q4 | 52,592,482 | $1,490,407,290 | +$95,537,202 | 2,833.99% | 145 |
| 2020 Q3 | 49,347,382 | $1,242,933,966 | -$27,121,551 | 2,514% | 146 |
| 2020 Q2 | 49,867,878 | $1,216,503,031 | +$35,616,766 | 2,441.99% | 135 |
| 2020 Q1 | 49,293,392 | $729,753,856 | -$25,443,570 | 1,480% | 120 |
| 2019 Q4 | 50,824,274 | $824,868,235 | +$129,782,986 | 1,622.98% | 125 |
| 2019 Q3 | 42,605,836 | $553,941,602 | -$12,407,642 | 1,300% | 104 |
| 2019 Q2 | 43,043,659 | $557,396,588 | +$27,061,482 | 1,297% | 108 |
| 2019 Q1 | 40,565,324 | $639,315,834 | +$98,451,099 | 1,576.01% | 104 |
| 2018 Q4 | 31,723,980 | $638,582,573 | +$17,643,380 | 2,012.94% | 95 |
| 2018 Q3 | 34,009,383 | $845,132,934 | -$21,938,902 | 2,485% | 107 |
| 2018 Q2 | 31,084,230 | $853,299,930 | +$18,852,772 | 2,745.02% | 107 |
| 2018 Q1 | 34,209,499 | $1,053,625,660 | -$32,732,651 | 3,079.99% | 118 |
| 2017 Q4 | 34,942,553 | $1,246,690,005 | +$167,196,133 | 3,575% | 113 |
| 2017 Q3 | 27,414,652 | $754,198,335 | -$1,518,505 | 2,755% | 82 |
| 2017 Q2 | 27,519,844 | $726,508,386 | +$33,692,658 | 2,639.89% | 84 |
| 2017 Q1 | 26,244,438 | $545,878,202 | +$45,353,932 | 2,080% | 75 |
| 2016 Q4 | 26,079,545 | $539,838,722 | +$12,164,864 | 2,070% | 79 |
| 2016 Q3 | 28,646,674 | $464,359,406 | -$1,079,896 | 1,621% | 74 |
| 2016 Q2 | 28,754,017 | $391,052,386 | +$16,928,575 | 1,360% | 76 |
| 2016 Q1 | 27,202,594 | $474,934,380 | -$25,985,490 | 1,746% | 82 |
| 2015 Q4 | 27,209,685 | $929,575,673 | +$189,567,502 | 3,415.98% | 101 |
| 2015 Q3 | 21,644,614 | $644,108,702 | +$32,787,105 | 2,976% | 76 |
| 2015 Q2 | 20,375,790 | $651,623,876 | +$15,879,760 | 3,198% | 86 |
| 2015 Q1 | 20,572,529 | $426,440,171 | +$18,581,352 | 2,072.98% | 69 |
| 2014 Q4 | 19,756,513 | $334,667,612 | +$8,319,858 | 1,693.93% | 67 |
| 2014 Q3 | 15,656,921 | $302,653,761 | -$45,141,249 | 1,933.04% | 80 |
| 2014 Q2 | 16,359,430 | $556,110,916 | +$155,037,820 | 3,400% | 97 |
| 2014 Q1 | 11,832,924 | $372,736,175 | +$371,917,123 | 3,150% | 65 |