| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Farallon Capital Partners, L.P. | 7.9% | +16% | $435,923,419 | +$63,471,970 | 13,262,045 | +17% | Dapice Joshua J. | 31 Dec 2024 |
| JANUS HENDERSON GROUP PLC | 6.1% | +6.7% | $530,327,722 | +$35,740,771 | 11,356,054 | +7.2% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| WELLINGTON MANAGEMENT GROUP LLP | 5.5% | $377,455,761 | 10,259,738 | Wellington Management Group LLP | 30 Jun 2025 | |||
| FMR LLC | 5% | $439,058,769 | 9,401,687 | FMR LLC | 30 Sep 2025 | |||
| BAKER BROS. ADVISORS LP | 5% | $358,678,428 | 9,364,972 | Baker Bros. Advisors LP | 30 Jun 2025 | |||
| BlackRock, Inc. | 4.5% | $334,288,717 | 8,399,214 | BlackRock, Inc. | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | 8.4% | 15,663,094 | -0.63% | 0.01% | $731,466,490 |
| FARALLON CAPITAL MANAGEMENT LLC | 7.9% | 14,625,692 | +2.1% | 3.9% | $683,019,816 |
| JANUS HENDERSON GROUP PLC | 6.1% | 11,356,054 | +7.2% | 0.24% | $530,307,153 |
| WELLINGTON MANAGEMENT GROUP LLP | 5.3% | 9,813,436 | -4.4% | 0.08% | $458,287,462 |
| BAKER BROS. ADVISORS LP | 5.1% | 9,455,357 | +0.97% | 3.2% | $441,565,172 |
| FMR LLC | 5.1% | 9,401,687 | +13% | 0.02% | $439,058,770 |
| BlackRock, Inc. | 4.5% | 8,327,758 | -3.9% | 0.01% | $388,906,300 |
| Nextech Invest, Ltd. | 4.1% | 7,601,087 | 0% | 54% | $354,970,763 |
| Paradigm Biocapital Advisors LP | 3.3% | 6,223,291 | +2.1% | 8.6% | $290,627,690 |
| Bellevue Group AG | 3% | 5,573,838 | +22% | 5.4% | $260,298,235 |
| STATE STREET CORP | 2.8% | 5,254,639 | +11% | 0.01% | $245,391,641 |
| T. Rowe Price Investment Management, Inc. | 2.6% | 4,782,318 | +2% | 0.14% | $223,335,000 |
| Alphabet Inc. | 2.2% | 4,133,277 | 0% | 8% | $193,024,036 |
| BVF INC/IL | 2.1% | 3,974,913 | -20% | 7.5% | $185,628,437 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.1% | 3,873,706 | -18% | 0.02% | $180,903,000 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2% | 3,650,342 | +7.9% | 2.6% | $170,470,971 |
| Holocene Advisors, LP | 1.8% | 3,437,283 | -5.4% | 0.37% | $160,521,116 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.7% | 3,145,640 | +5.1% | 0.01% | $146,932,051 |
| Woodline Partners LP | 1.6% | 2,915,883 | +0.01% | 0.64% | $136,171,736 |
| a16z Capital Management, L.L.C. | 1.5% | 2,748,523 | 0% | 9.2% | $128,356,024 |
| Casdin Capital, LLC | 1.4% | 2,647,333 | -8.3% | 10% | $123,630,451 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1.4% | 2,513,967 | +52% | 0.49% | $117,402,259 |
| JPMORGAN CHASE & CO | 1.3% | 2,498,327 | -12% | 0.01% | $116,671,883 |
| GENERAL ATLANTIC, L.P. | 1.3% | 2,474,428 | 3.5% | $115,555,788 | |
| Lunate Capital Ltd | 1.2% | 2,196,200 | 0% | 46% | $102,562,540 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 71,490 | $6,618,404 | +$537,245 | $79.65 | 12 |
| 2025 Q3 | 191,763,478 | $8,954,921,999 | +$87,457,260 | $46.70 | 316 |
| 2025 Q2 | 190,726,235 | $7,017,009,498 | -$4,134,286 | $36.79 | 305 |
| 2025 Q1 | 191,051,104 | $6,776,435,868 | -$111,944,443 | $35.36 | 280 |
| 2024 Q4 | 193,055,963 | $8,445,467,181 | +$749,026,007 | $43.74 | 278 |
| 2024 Q3 | 168,830,185 | $7,656,108,748 | +$1,876,917 | $45.35 | 252 |
| 2024 Q2 | 168,412,310 | $6,536,360,101 | +$376,492,769 | $38.81 | 222 |
| 2024 Q1 | 158,827,884 | $5,118,999,293 | +$13,473,215 | $32.23 | 205 |
| 2023 Q4 | 296,688 | $8,528,142 | +$6,436,357 | $29.02 | 4 |
| 2023 Q3 | 111,953,251 | $3,098,818,648 | +$8,763,005 | $27.68 | 163 |
| 2023 Q2 | 111,575,552 | $2,984,131,046 | +$99,855,971 | $26.75 | 136 |
| 2023 Q1 | 108,080,099 | $2,339,923,951 | +$420,541,164 | $21.66 | 147 |
| 2022 Q4 | 88,205,394 | $2,101,077,413 | +$33,054,778 | $23.82 | 131 |
| 2022 Q3 | 81,009,621 | $1,597,454,259 | +$212,990,118 | $19.72 | 128 |
| 2022 Q2 | 71,040,590 | $1,384,537,160 | +$38,056,673 | $19.49 | 122 |
| 2022 Q1 | 73,938,192 | $1,885,138,975 | +$15,749,801 | $25.51 | 121 |
| 2021 Q4 | 73,268,441 | $1,844,183,801 | -$50,186,441 | $25.17 | 111 |
| 2021 Q3 | 72,282,662 | $1,988,520,078 | +$49,812,476 | $27.51 | 111 |
| 2021 Q2 | 70,346,720 | $2,232,691,951 | +$90,768,509 | $31.74 | 125 |
| 2021 Q1 | 66,423,819 | $3,047,429,763 | +$426,553,376 | $45.88 | 125 |
| 2020 Q4 | 57,342,308 | $2,270,190,182 | +$131,226,916 | $39.59 | 114 |
| 2020 Q3 | 56,953,491 | $1,981,063,717 | +$340,135,585 | $34.80 | 87 |
| 2020 Q2 | 46,885,624 | $1,478,096,925 | +$22,726,406 | $31.57 | 72 |
| 2020 Q1 | 46,880,534 | $1,025,105,285 | +$1,024,831,007 | $21.91 | 71 |