| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | $140,627,089 | 15,302,186 | RA Capital Healthcare Fund, L.P. | 11 Dec 2025 | |||
| FMR LLC | 15% | +41% | $47,019,585 | +$23,675,056 | 12,811,876 | +101% | FMR LLC | 30 Jun 2025 |
| Opaleye Management Inc. | 5.3% | $45,149,551 | 4,912,900 | Opaleye Management Inc. | 12 Dec 2025 | |||
| BlackRock, Inc. | 5.4% | $45,886,185 | 4,881,509 | BlackRock, Inc. | 30 Sep 2025 | |||
| Invus Global Management, LLC | 5.4% | $34,090,000 | 4,870,000 | Raymond Debbane | 18 Sep 2025 | |||
| Nantahala Capital Management, LLC | 4.9% | -41% | $8,288,148 | -$6,115,332 | 2,857,982 | -42% | Nantahala Capital Management, LLC | 31 Dec 2024 |
| Filer | Ownership | Holdings Value | Nb Shares | Share Change % |
|---|---|---|---|---|
| FEDERATED HERMES, INC. | 15% | $131,926,293 | 14,034,712 | 0% |
| FMR LLC | 14% | $119,983,791 | 12,764,233 | -0.37% |
| BlackRock, Inc. | 5.4% | $47,041,697 | 5,004,436 | +23% |
| Siren, L.L.C. | 5.3% | $45,778,000 | 4,870,000 | |
| VANGUARD GROUP INC | 4.8% | $41,454,771 | 4,410,082 | +9.6% |
| Blackstone Inc. | 3.3% | $28,424,651 | 3,023,899 | -15% |
| MANGROVE PARTNERS IM, LLC | 3.1% | $27,092,201 | 2,882,149 | +25% |
| MARSHALL WACE, LLP | 2.9% | $25,646,160 | 2,728,315 | -5.5% |
| UBS Group AG | 2.9% | $25,342,193 | 2,695,978 | -11% |
| GREAT POINT PARTNERS LLC | 2.6% | $23,047,005 | 2,451,809 | -19% |
| Vivo Capital, LLC | 2.3% | $19,856,861 | 2,112,432 | 0% |
| Affinity Asset Advisors, LLC | 2.3% | $19,740,000 | 2,100,000 | -4.5% |
| STATE STREET CORP | 2.3% | $19,659,874 | 2,091,476 | +152% |
| Integral Health Asset Management, LLC | 2.2% | $18,800,000 | 2,000,000 | +11% |
| CAXTON CORP | 2.1% | $18,676,089 | 1,986,818 | +24% |
| GEODE CAPITAL MANAGEMENT, LLC | 2% | $17,369,547 | 1,847,384 | +8% |
| Balyasny Asset Management L.P. | 2% | $17,133,643 | 1,822,728 | |
| Rosalind Advisors, Inc. | 1.9% | $16,987,698 | 1,807,202 | +3.8% |
| BANK OF AMERICA CORP /DE/ | 1.4% | $12,078,642 | 1,284,962 | +1579% |
| Point72 Asset Management, L.P. | 1.2% | $10,879,651 | 1,157,410 | +447% |
| Woodline Partners LP | 1% | $8,825,134 | 938,844 | -51% |
| STEMPOINT CAPITAL LP | 0.99% | $8,625,722 | 917,630 | +42% |
| Opaleye Management Inc. | 0.97% | $8,492,355 | 903,442 | 0% |
| 22NW, LP | 0.89% | $7,714,138 | 820,653 | |
| ADAR1 Capital Management, LLC | 0.88% | $7,670,165 | 815,975 | -18% |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 15 | $35 | +$35 | $2.33 | 1 |
| 2025 Q3 | 86,920,142 | $817,052,884 | +$108,361,486 | $9.40 | 115 |
| 2025 Q2 | 77,913,169 | $347,492,575 | +$151,536,991 | $4.46 | 91 |
| 2025 Q1 | 45,040,344 | $130,615,009 | -$811,008 | $2.90 | 76 |
| 2024 Q4 | 43,207,187 | $211,713,139 | +$30,093,703 | $4.90 | 71 |
| 2024 Q3 | 38,544,894 | $186,942,117 | -$3,938,832 | $4.85 | 59 |
| 2024 Q2 | 39,525,913 | $169,961,526 | +$54,178,979 | $4.30 | 51 |
| 2024 Q1 | 27,042,621 | $68,962,251 | +$246,855 | $2.55 | 33 |
| 2023 Q4 | 28,952,301 | $28,740,703 | +$4,794,203 | $0.9925 | 31 |
| 2023 Q3 | 23,889,501 | $31,534,322 | -$458,983 | $1.32 | 29 |
| 2023 Q2 | 24,223,878 | $47,962,915 | +$49,685 | $1.98 | 28 |
| 2023 Q1 | 24,226,408 | $46,514,454 | -$475,671 | $1.92 | 31 |
| 2022 Q4 | 24,450,852 | $50,611,801 | +$2,511,816 | $2.07 | 34 |
| 2022 Q3 | 1,407,290 | $3,857,000 | -$122 | $3.97 | 2 |
| 2022 Q2 | 0 | $0 | -$2,000 | 0 | |
| 2022 Q1 | 7,085,710 | $23,951,000 | -$2,289,057 | $3.38 | 19 |
| 2021 Q4 | 7,529,707 | $35,989,000 | +$22,778,301 | $4.78 | 21 |
| 2021 Q3 | 2,373,215 | $17,647,000 | +$1,206,769 | $7.48 | 13 |
| 2021 Q2 | 2,211,492 | $31,558,000 | -$1,377,630 | $14.27 | 11 |
| 2021 Q1 | 2,477,026 | $17,487,000 | -$208,256 | $7.06 | 10 |
| 2020 Q4 | 2,506,346 | $30,230,000 | +$30,230,001 | $11.99 | 7 |