| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 8.9% | $263,130,477 | 5,604,483 | Baker Bros. Advisors LP | 31 Mar 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 8.7% | $542,844,252 | 5,561,359 | RA Capital Management, L.P. | 30 Jun 2025 | |||
| VANGUARD GROUP INC | 7.5% | $504,589,163 | 4,996,427 | The Vanguard Group | 30 Sep 2025 | |||
| PERCEPTIVE ADVISORS LLC | 6.8% | $207,680,555 | 4,423,441 | Perceptive Advisors LLC | 31 Mar 2025 | |||
| BlackRock, Inc. | 6.9% | $204,922,665 | 4,364,700 | BlackRock, Inc. | 31 Mar 2025 | |||
| PRIMECAP MANAGEMENT CO/CA/ | 6.4% | -16% | $430,506,130 | -$62,126,826 | 4,262,859 | -13% | PRIMECAP MANAGEMENT CO/CA/ | 30 Sep 2025 |
| GOLDMAN SACHS GROUP INC | 3% | $85,398,854 | 1,818,932 | THE GOLDMAN SACHS GROUP, INC. | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BlackRock, Inc. | 9.5% | 6,302,215 | +0.55% | 0.01% | $636,460,694 |
| RA CAPITAL MANAGEMENT, L.P. | 8.6% | 5,681,359 | +2.2% | 7.1% | $573,760,445 |
| BAKER BROS. ADVISORS LP | 8.4% | 5,604,483 | 0% | 4.1% | $565,996,738 |
| VANGUARD GROUP INC | 7.5% | 4,996,427 | +39% | 0.01% | $504,589,163 |
| PRIMECAP MANAGEMENT CO/CA/ | 6.4% | 4,262,859 | -13% | 0.33% | $430,506,130 |
| NEA Management Company, LLC | 4.4% | 2,909,956 | 0% | 16% | $293,876,456 |
| PERCEPTIVE ADVISORS LLC | 3.7% | 2,438,969 | +0.85% | 7.2% | $246,311,479 |
| FMR LLC | 3.2% | 2,145,183 | +9.8% | 0.01% | $216,642,009 |
| STATE STREET CORP | 3.1% | 2,028,651 | +6.3% | 0.01% | $204,873,464 |
| GOLDMAN SACHS GROUP INC | 2.9% | 1,893,663 | +9.2% | 0.03% | $191,241,026 |
| FEDERATED HERMES, INC. | 2.6% | 1,727,885 | +2.5% | 0.31% | $174,499,106 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.1% | 1,399,897 | +4.4% | 0.02% | $141,377,000 |
| Driehaus Capital Management LLC | 2.1% | 1,383,775 | +9% | 1% | $139,747,437 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.1% | 1,362,829 | +3.9% | 0.01% | $137,654,057 |
| Polar Capital Holdings Plc | 1.9% | 1,244,932 | -0.47% | 0.61% | $125,725,683 |
| JPMORGAN CHASE & CO | 1.8% | 1,188,069 | +52% | 0.01% | $119,983,088 |
| JANUS HENDERSON GROUP PLC | 1.7% | 1,160,887 | -18% | 0.05% | $117,237,978 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1.6% | 1,069,004 | -34% | 0.45% | $107,958,714 |
| ALKEON CAPITAL MANAGEMENT LLC | 1.5% | 1,017,700 | 0% | 0.46% | $102,777,523 |
| ALLIANCEBERNSTEIN L.P. | 1.5% | 979,682 | +1494% | 0.03% | $98,938,085 |
| Checkpoint Capital L.P. | 1.2% | 763,707 | -28% | 26% | $77,126,770 |
| Rock Springs Capital Management LP | 1.1% | 717,102 | -17% | 4.2% | $72,420,131 |
| Pictet Asset Management Holding SA | 1% | 683,017 | +64% | 0.07% | $68,952,135 |
| Capital Research Global Investors | 0.9% | 598,247 | 0.01% | $60,416,965 | |
| Woodline Partners LP | 0.87% | 580,183 | +13% | 0.28% | $58,592,681 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 17,828 | $1,908,552 | -$23,455,203 | $107.04 | 6 |
| 2025 Q3 | 70,889,646 | $7,159,045,368 | +$449,473,155 | $100.99 | 262 |
| 2025 Q2 | 66,543,505 | $4,204,958,379 | +$136,584,157 | $63.19 | 225 |
| 2025 Q1 | 64,595,384 | $3,424,911,068 | -$18,829,114 | $52.97 | 226 |
| 2024 Q4 | 64,917,500 | $3,634,216,597 | -$154,967,284 | $55.98 | 202 |
| 2024 Q3 | 67,633,760 | $3,542,730,734 | -$89,041,484 | $52.39 | 178 |
| 2024 Q2 | 69,303,085 | $2,846,274,465 | +$55,480,400 | $41.06 | 165 |
| 2024 Q1 | 67,970,508 | $2,943,611,078 | +$57,195,827 | $43.33 | 169 |
| 2023 Q4 | 80,273 | $3,690,150 | -$183,237 | $45.97 | 3 |
| 2023 Q3 | 68,143,293 | $1,562,080,097 | +$52,384,052 | $22.92 | 143 |
| 2023 Q2 | 66,212,640 | $1,092,126,780 | +$94,872,230 | $16.49 | 116 |
| 2023 Q1 | 56,555,459 | $1,008,940,021 | -$50,412,022 | $17.84 | 124 |
| 2022 Q4 | 62,315,169 | $1,814,633,448 | +$85,319,986 | $29.12 | 115 |
| 2022 Q3 | 59,485,390 | $1,445,333,394 | +$425,331,067 | $24.50 | 96 |
| 2022 Q2 | 44,285,623 | $183,787,988 | -$10,542,625 | $4.15 | 77 |
| 2022 Q1 | 48,387,008 | $557,366,977 | +$5,264,240 | $11.52 | 101 |
| 2021 Q4 | 48,382,013 | $482,849,595 | -$577,340 | $9.98 | 89 |
| 2021 Q3 | 47,716,597 | $623,208,206 | +$5,067,526 | $13.06 | 92 |
| 2021 Q2 | 47,332,279 | $902,596,313 | -$4,691,524 | $19.58 | 100 |
| 2021 Q1 | 47,577,204 | $1,011,968,096 | +$147,674,681 | $21.27 | 121 |
| 2020 Q4 | 40,465,979 | $1,199,975,923 | +$38,678,744 | $29.73 | 113 |
| 2020 Q3 | 39,249,591 | $850,611,960 | -$43,715,003 | $21.67 | 114 |
| 2020 Q2 | 41,219,166 | $919,171,883 | +$11,797,880 | $22.30 | 87 |
| 2020 Q1 | 40,800,199 | $620,976,603 | -$33,703,535 | $15.22 | 79 |
| 2019 Q4 | 39,986,197 | $918,077,101 | +$204,869,654 | $22.96 | 88 |
| 2019 Q3 | 31,230,077 | $674,245,813 | +$64,824,294 | $21.59 | 83 |
| 2019 Q2 | 28,187,960 | $620,070,946 | +$8,597,860 | $22.00 | 81 |
| 2019 Q1 | 30,856,102 | $845,856,903 | -$21,943,308 | $27.41 | 84 |
| 2018 Q4 | 31,656,058 | $850,970,460 | +$12,832,028 | $26.88 | 72 |
| 2018 Q3 | 30,339,252 | $884,997,537 | -$10,279,567 | $29.17 | 74 |
| 2018 Q2 | 31,030,594 | $966,429,352 | +$213,480,320 | $31.26 | 84 |
| 2018 Q1 | 20,379,585 | $405,555,382 | -$5,859,479 | $19.90 | 52 |
| 2017 Q4 | 21,606,212 | $627,880,658 | +$506,806,498 | $29.06 | 64 |