Sage Therapeutics, Inc. - Common Stock, par value $0.0001 per share (the "Common Stock") (SAGE) Institutional Ownership

13F Institutional Holders and Ownership History from Q3 2014 to Q3 2025

Type / Class: Equity / Common Stock, par value $0.0001 per share (the "Common Stock")
Symbol: SAGE
Shares outstanding: 62,650,155
Price per share: $8.94
All holders as of 30 Sep 2025: Q3 2025
Total 13F shares: 26,706
Total reported value: $494,024
% of total 13F portfolios: 0%
Share change: -48,841,879
Value change: -$445,437,020
Number of holders: 4
Price from insider filings: $8.94

Reported Shares, Excluding Options vs Price

Reported Value, Excluding Options

Total Investors

Significant Owners of Sage Therapeutics, Inc. - Common Stock, par value $0.0001 per share (the "Common Stock") (SAGE) based on Schedule 13D/G filings

Filer	Ownership	Change %	Holdings Value	Net Change	Nb Shares	Change %	Reporting Name	Report Period
BlackRock, Inc.	7.2%		$30,577,282		4,425,077		BlackRock, Inc.	31 Mar 2025
VANGUARD GROUP INC	5.2%	-34%	$25,440,598	-$12,248,739	3,265,802	-32%	The Vanguard Group	30 Jun 2025
RTW INVESTMENTS, LP	4.9%		$20,746,377		3,002,370		RTW Investments, LP	31 Dec 2024
BB BIOTECH AG	1.9%		$8,143,456		1,178,503		BB Biotech AG	13 Jan 2025
MORGAN STANLEY	1.6%	-83%	$6,995,249	-$24,396,826	1,012,337	-78%	Morgan Stanley	28 Feb 2025
FMR LLC	0.8%	-84%	$3,461,325	-$24,987,182	500,915	-88%	FMR LLC	28 Feb 2025

As of 30 Sep 2025, 4 institutional investors reported holding 26,706 shares of Sage Therapeutics, Inc. - Common Stock, par value $0.0001 per share (the "Common Stock") (SAGE). This represents 0.04% of the company’s total 62,650,155 outstanding shares.

Institutional Holders of Sage Therapeutics, Inc. - Common Stock, par value $0.0001 per share (the "Common Stock") (SAGE) across Reporting Periods

Period	Reported Shares, Excl. Options	Value, Excl. Options	Value Change	Puts Notional Value	Calls Notional Value	Price (Median)	Investors
2025 Q3	26,706	$494,024	-$445,437,020	$0	$0	$8.94	4
2025 Q2	48,874,647	$445,736,286	-$14,688,112	$4,014,624	$6,863,355	$9.12	190
2025 Q1	51,753,624	$411,497,270	+$29,111,640	$2,477,220	$1,446,105	$7.95	196
2024 Q4	51,167,791	$277,852,273	-$6,199,512	$635,310	$1,445,466	$5.43	173
2024 Q3	51,256,195	$370,077,971	-$24,546,944	$1,508,980	$2,629,417	$7.22	172
2024 Q2	53,516,131	$581,166,333	-$65,110,541	$2,113,356	$8,858,902	$10.86	191
2024 Q1	58,171,307	$1,090,142,632	+$31,196,602	$3,571,644	$3,178,104	$18.74	197
2023 Q4	70,968	$1,548,992	-$3,114,023			$21.67	3
2023 Q3	58,182,753	$1,197,410,922	-$2,918,847	$5,265,306	$12,392,102	$20.58	186
2023 Q2	53,436,575	$2,512,369,843	+$37,777,579	$12,295,480	$17,368,533	$47.02	218
2023 Q1	52,674,023	$2,209,884,530	+$61,583,013	$7,628,328	$12,344,368	$41.96	207
2022 Q4	51,593,035	$1,967,203,395	+$2,023,581	$3,192,318	$15,767,000	$38.14	197
2022 Q3	44,958,338	$1,760,616,708	+$7,132,722	$3,736,000	$16,099,248	$39.16	177
2022 Q2	50,438,386	$1,626,117,855	+$35,142,248	$6,767,000	$16,028,500	$32.30	182
2022 Q1	49,311,246	$1,632,399,366	-$34,521,971	$17,877,000	$25,037,500	$33.10	184
2021 Q4	44,653,689	$1,899,776,557	+$38,913,870	$28,207,638	$52,534,700	$42.54	196
2021 Q3	49,038,043	$2,173,019,217	-$110,629,145	$29,226,431	$13,253,550	$44.31	214
2021 Q2	50,438,467	$2,864,714,376	-$182,870,528	$107,493,479	$51,097,845	$56.81	248
2021 Q1	53,055,268	$3,972,359,046	-$90,475,852	$84,040,480	$38,218,675	$74.85	255
2020 Q4	53,369,406	$4,617,072,604	+$45,127,071	$39,358,239	$40,749,535	$86.51	240
2020 Q3	53,525,011	$3,268,922,370	-$23,439,447	$18,980,000	$50,507,000	$61.12	218
2020 Q2	53,722,571	$2,238,893,601	+$1,230,779	$15,801,000	$27,866,646	$41.58	202
2020 Q1	54,893,642	$1,576,504,134	-$221,437,910	$11,807,000	$13,294,000	$28.72	206
2019 Q4	55,563,735	$4,011,250,514	-$405,793,272	$86,155,000	$99,415,000	$72.19	250
2019 Q3	58,165,463	$8,160,782,684	+$20,674,357	$110,671,000	$88,080,000	$140.29	269
2019 Q2	58,049,567	$10,625,544,842	+$1,066,293,404	$139,820,000	$88,902,000	$183.09	260
2019 Q1	55,890,231	$8,889,736,233	+$1,101,970,088	$85,517,000	$108,039,000	$159.05	253
2018 Q4	49,698,860	$4,758,304,171	+$6,321,061	$88,018,000	$121,505,000	$95.79	236
2018 Q3	48,674,379	$6,874,382,610	+$63,075,095	$57,932,009	$56,084,000	$141.25	269
2018 Q2	48,394,227	$7,569,312,760	+$240,027,264	$54,080,000	$55,006,000	$156.53	262
2018 Q1	47,434,352	$7,633,296,047	+$642,909,882	$48,758,000	$56,745,000	$161.07	242
2017 Q4	44,045,802	$7,247,138,701	+$673,803,575	$219,367,000	$274,226,000	$164.71	217
2017 Q3	39,314,584	$2,450,400,062	+$48,577,364	$100,415,000	$55,579,000	$62.30	168
2017 Q2	38,446,334	$3,055,447,026	+$15,135,912	$125,006,000	$157,898,000	$79.64	187
2017 Q1	37,870,622	$2,690,953,691	+$271,120,445	$135,278,000	$49,605,000	$71.07	184
2016 Q4	36,733,164	$1,875,784,404	-$47,772,048	$30,800,000	$24,846,000	$51.06	160
2016 Q3	37,761,725	$1,736,095,970	+$398,894,748	$20,182,000	$18,944,000	$46.05	149
2016 Q2	30,208,087	$911,383,018	+$28,970,814	$34,511,000	$49,704,550	$30.13	137
2016 Q1	29,072,784	$931,883,546	+$174,139,464	$2,100,000	$2,664,000	$32.06	138
2015 Q4	23,454,666	$1,367,396,352	+$159,360,560	$6,949,000	$4,268,000	$58.30	133
2015 Q3	27,177,579	$1,150,149,509	+$22,835,759	$4,177,000	$9,327,000	$42.32	125
2015 Q2	26,330,046	$1,922,059,498	+$370,796,540	$9,081,000	$3,066,000	$73.00	120
2015 Q1	21,504,972	$1,080,191,161	+$66,645,182			$50.23	89
2014 Q4	19,690,657	$720,748,309	+$20,813,593			$36.60	70
2014 Q3	18,894,149	$595,167,000	+$595,166,610			$31.50	50