| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Growth Equity Opportunities 17, LLC | 12% | $87,362,412 | 24,471,264 | Growth Equity Opportunities 17, LLC | 12 Nov 2025 | |||
| Farallon Capital Partners, L.P. | 10% | $53,403,839 | 18,288,986 | Dapice Joshua J. | 31 Dec 2024 | |||
| Bain Capital Life Sciences Fund II, L.P. | 10% | $51,393,813 | 17,600,621 | Bain Capital Life Sciences Fund II, L.P. | 25 Mar 2025 | |||
| Flynn James E | 6.7% | $48,441,330 | 13,569,000 | Deerfield Mgmt, L.P. | 30 Oct 2025 | |||
| Venrock Healthcare Capital Partners III, L.P. | 7.3% | +42% | $45,271,324 | +$13,064,544 | 12,681,043 | +41% | Venrock Healthcare Capital Partners III, L.P. | 30 Sep 2025 |
| Nantahala Capital Management, LLC | 5.1% | $31,328,089 | 8,775,375 | Nantahala Capital Management, LLC | 30 Sep 2025 | |||
| BlackRock, Inc. | 4.8% | $29,684,104 | 8,314,875 | BlackRock, Inc. | 30 Sep 2025 | |||
| Frazier Life Sciences Public Fund, L.P. | 3.9% | -39% | $22,192,024 | -$15,518,946 | 6,745,296 | -41% | Frazier Life Sciences Public Fund, L.P. | 30 Jun 2025 |
| WELLINGTON MANAGEMENT GROUP LLP | 3.2% | $16,006,430 | 5,481,654 | Wellington Management Group LLP | 31 Dec 2024 | |||
| Vestal Point Capital, LP | 2.3% | -67% | $14,333,550 | -$24,133,200 | 4,015,000 | -63% | Vestal Point Capital, LP | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| NEA Management Company, LLC | 14% | 24,471,264 | 0% | 4.8% | $87,362,412 |
| Bain Capital Life Sciences Investors, LLC | 10% | 17,600,621 | 0% | 4.2% | $62,834,217 |
| VR ADVISER, LLC | 7.3% | 12,681,043 | +43% | 2.5% | $45,271,324 |
| TCG Crossover Management, LLC | 7.2% | 12,362,205 | 0% | 2.2% | $44,133,072 |
| Frazier Life Sciences Management, L.P. | 6.6% | 11,462,301 | 0% | 1.2% | $40,920,415 |
| Nantahala Capital Management, LLC | 5.1% | 8,775,375 | +5.4% | 1.9% | $31,328,089 |
| BlackRock, Inc. | 4.9% | 8,448,240 | -14% | 0% | $30,160,217 |
| VANGUARD GROUP INC | 4.8% | 8,313,194 | -1.7% | 0% | $29,678,103 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4.6% | 7,964,000 | 0% | 0.44% | $28,431,480 |
| Vestal Point Capital, LP | 2.3% | 4,015,000 | -64% | 0.65% | $14,333,550 |
| Rosalind Advisors, Inc. | 2.3% | 4,000,000 | +51% | 5.2% | $14,280,000 |
| EMERALD ADVISERS, LLC | 2% | 3,529,324 | -0.14% | 0.4% | $12,599,687 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.6% | 2,795,661 | -5.9% | 0% | $9,982,589 |
| WELLINGTON MANAGEMENT GROUP LLP | 1.5% | 2,644,000 | -21% | 0% | $9,439,079 |
| FARALLON CAPITAL MANAGEMENT LLC | 1.4% | 2,500,000 | -63% | 0.05% | $8,925,000 |
| Sofinnova Investments, Inc. | 1.4% | 2,427,724 | -1.2% | 0.53% | $8,666,975 |
| STATE STREET CORP | 1.4% | 2,359,858 | -4% | 0% | $8,424,693 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1.2% | 2,151,358 | -1.6% | 0.4% | $7,680,348 |
| ADAR1 Capital Management, LLC | 1.2% | 1,988,288 | -45% | 0.71% | $7,098,188 |
| MORGAN STANLEY | 1.1% | 1,917,827 | +401% | 0% | $6,846,643 |
| Affinity Asset Advisors, LLC | 0.87% | 1,500,000 | +200% | 0.5% | $5,355,000 |
| SPHERA FUNDS MANAGEMENT LTD. | 0.78% | 1,350,333 | +3.1% | 1.1% | $4,820,689 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0.76% | 1,309,236 | +17% | 4.6% | $4,673,973 |
| AXA Investment Managers S.A. | 0.61% | 1,053,261 | 0% | 0.01% | $3,760,142 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.56% | 963,798 | -3.2% | 0% | $3,440,759 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 45,573 | $275,283 | +$275,283 | 603.09% | 2 |
| 2025 Q3 | 163,008,726 | $581,790,219 | -$17,790,436 | 357% | 124 |
| 2025 Q2 | 167,625,869 | $382,185,936 | +$4,604,988 | 228% | 121 |
| 2025 Q1 | 165,084,968 | $457,299,983 | +$4,913,486 | 277% | 133 |
| 2024 Q4 | 162,840,037 | $499,923,364 | -$4,524,305 | 307% | 133 |
| 2024 Q3 | 160,489,937 | $680,420,129 | +$47,578,385 | 424% | 124 |
| 2024 Q2 | 148,180,429 | $597,178,838 | +$107,081,010 | 403% | 130 |
| 2024 Q1 | 121,071,712 | $602,921,814 | +$11,925,968 | 498% | 120 |
| 2023 Q4 | 174,146 | $818,486 | +$489,618 | 470% | 2 |
| 2023 Q3 | 116,705,553 | $441,157,559 | +$105,083,400 | 378% | 82 |
| 2023 Q2 | 89,090,177 | $284,756,848 | +$19,902,172 | 319.5% | 76 |
| 2023 Q1 | 83,445,307 | $162,717,384 | +$6,796,523 | 195% | 66 |
| 2022 Q4 | 79,984,853 | $123,981,605 | +$91,998 | 155% | 52 |
| 2022 Q3 | 79,906,961 | $123,859,636 | +$4,272,578 | 155% | 47 |
| 2022 Q2 | 77,182,347 | $117,316,451 | +$2,429,333 | 152% | 46 |
| 2022 Q1 | 75,830,602 | $99,337,996 | +$1,523,864 | 131% | 44 |
| 2021 Q4 | 74,670,485 | $92,591,002 | -$970,671 | 123.99% | 45 |
| 2021 Q3 | 75,009,866 | $103,522,069 | -$1,783,888 | 138% | 54 |
| 2021 Q2 | 75,786,104 | $128,841,285 | +$601,006 | 169.97% | 69 |
| 2021 Q1 | 75,182,589 | $156,419,847 | +$111,668,995 | 208% | 76 |
| 2020 Q4 | 18,648,466 | $21,448,582 | -$736,380 | 115.01% | 60 |
| 2020 Q3 | 14,245,607 | $15,529,392 | -$3,988,654 | 108.95% | 60 |
| 2020 Q2 | 14,990,229 | $37,310,921 | +$356,994 | 249% | 64 |
| 2020 Q1 | 17,479,303 | $36,937,026 | +$5,370,973 | 212.04% | 64 |
| 2019 Q4 | 20,749,180 | $92,674,951 | +$30,682,627 | 447.97% | 72 |
| 2019 Q3 | 12,656,061 | $33,538,563 | -$4,315,620 | 265.01% | 67 |
| 2019 Q2 | 14,504,620 | $34,437,894 | -$13,260,157 | 237% | 68 |
| 2019 Q1 | 16,256,183 | $119,809,460 | -$5,762,292 | 737.04% | 77 |
| 2018 Q4 | 17,070,800 | $129,225,149 | -$12,353,452 | 757% | 73 |
| 2018 Q3 | 17,972,485 | $200,571,354 | +$36,315,217 | 1,115.92% | 77 |
| 2018 Q2 | 14,701,120 | $166,423,152 | +$22,049,661 | 1,132.03% | 72 |
| 2018 Q1 | 12,952,324 | $119,157,226 | +$8,214,763 | 919.97% | 56 |
| 2017 Q4 | 11,173,720 | $165,817,000 | +$102,203,499 | 1,483.89% | 46 |
| 2017 Q3 | 4,412,956 | $41,261,196 | +$5,281,858 | 935.01% | 15 |
| 2017 Q2 | 3,979,135 | $23,397,000 | +$23,397,027 | 588% | 16 |
| 2016 Q1 | 142 | $1,000 | $0 | 704.23% | 1 |