| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | $382M | 14.1M | FMR LLC | Dec 31, 2024 | |||
| Invus Global Management, LLC | 11.4% | $293M | 10.8M | Invus Public Equities, L.P. | Dec 31, 2024 | |||
| Redmile Group, LLC | 9.9% | $267M | 9.89M | Redmile Group, LLC | Dec 31, 2024 | |||
| Samsara BioCapital, L.P. | 7.2% | $260M | 6.99M | Srinivas Akkaraju | Oct 3, 2025 | |||
| PRICE T ROWE ASSOCIATES INC /MD/ | 7.2% | -22.2% | $256M | -$70M | 6.88M | -21.4% | T. Rowe Price Associates, Inc. | Sep 30, 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 116M | $4.32B | +$234M | $37.24 | 236 |
| 2025 Q2 | 110M | $3.89B | +$179M | $35.42 | 232 |
| 2025 Q1 | 105M | $3.37B | -$33.2M | $32.15 | 229 |
| 2024 Q4 | 104M | $4.51B | +$796M | $43.22 | 222 |
| 2024 Q3 | 86.9M | $696M | -$87.2M | $8.01 | 162 |
| 2024 Q2 | 84.9M | $707M | -$4.84M | $8.33 | 162 |
| 2024 Q1 | 84.8M | $1.51B | +$74.3M | $17.76 | 158 |
| 2023 Q4 | 415K | $7.79M | +$6.92M | $18.80 | 2 |
| 2023 Q3 | 53.9M | $382M | +$18.5M | $7.10 | 87 |
| 2023 Q2 | 51.2M | $386M | +$33.1M | $7.54 | 82 |
| 2023 Q1 | 46.8M | $374M | +$11.1M | $8.00 | 84 |
| 2022 Q4 | 45.3M | $410M | +$2.41M | $9.05 | 80 |
| 2022 Q3 | 43.4M | $301M | -$17.8M | $6.93 | 78 |
| 2022 Q2 | 44.9M | $246M | +$53M | $5.49 | 76 |
| 2022 Q1 | 31.1M | $401M | +$15M | $12.89 | 90 |
| 2021 Q4 | 29.7M | $738M | +$15.7M | $24.84 | 86 |
| 2021 Q3 | 28.8M | $950M | +$12.2M | $33.02 | 98 |
| 2021 Q2 | 28.2M | $816M | -$12M | $28.90 | 101 |
| 2021 Q1 | 27.8M | $1.41B | +$56.8M | $50.66 | 119 |
| 2020 Q4 | 24.7M | $1.2B | +$289M | $48.53 | 107 |
| 2020 Q3 | 21.2M | $376M | +$18.2M | $17.69 | 68 |
| 2020 Q2 | 20.2M | $368M | +$19.8M | $18.21 | 65 |
| 2020 Q1 | 19.2M | $232M | +$5.74M | $12.11 | 60 |
| 2019 Q4 | 18.6M | $246M | +$8.76M | $13.18 | 53 |
| 2019 Q3 | 18.1M | $162M | -$1.74M | $8.95 | 54 |
| 2019 Q2 | 17.8M | $282M | +$84.9M | $15.86 | 62 |
| 2019 Q1 | 14.1M | $265M | +$12.1M | $18.79 | 42 |
| 2018 Q4 | 13.4M | $308M | +$6.43M | $22.97 | 39 |
| 2018 Q3 | 13.1M | $334M | +$20.1M | $25.75 | 37 |
| 2018 Q2 | 12.5M | $190M | +$190M | $15.60 | 28 |