Septerna, Inc. - Common Stock (SEPN) Institutional Ownership

13F Institutional Holders and Ownership History from Q4 2024 to Q4 2025

Type / Class
Equity / Common Stock
Symbol
SEPN on Nasdaq
Shares outstanding
44,549,818
Price per share
$27.88
All holders as of 30 Sep 2025
Q3 2025
Total 13F shares
44,549,033
Total reported value
$837,968,810
% of total 13F portfolios
0%
Share change
+129,213
Value change
+$6,406,562
Number of holders
82
Price from insider filings
$27.88
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Septerna, Inc. - Common Stock (SEPN) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
Third Rock Ventures V, L.P. 14% 0% $35,553,181 6,215,591 0% Third Rock Ventures V, L.P. 31 Mar 2025
DRIEHAUS CAPITAL MANAGEMENT LLC 10% +49% $31,361,201 +$10,346,049 4,659,911 +49% DRIEHAUS CAPITAL MANAGEMENT LLC 31 May 2025
BIOTECHNOLOGY VALUE FUND L P 9.9% $25,145,829 4,396,124 BVF PARTNERS L P/IL 31 Mar 2025

As of 30 Sep 2025, 82 institutional investors reported holding 44,549,033 shares of Septerna, Inc. - Common Stock (SEPN). This represents 100% of the company’s total 44,549,818 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Septerna, Inc. - Common Stock (SEPN) together control 97% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
RA CAPITAL MANAGEMENT, L.P. 16% 6,995,858 0% 1.6% $131,592,089
TRV GP V, LLC 14% 6,215,591 0% 33% $116,915,267
Driehaus Capital Management LLC 11% 4,919,896 +5.1% 0.66% $92,543,244
TRV GP VI, LLC 9.5% 4,211,659 0% 72% $79,221,306
BVF INC/IL 9% 4,015,790 -8.7% 3.1% $75,537,010
SAMSARA BIOCAPITAL, LLC 7.1% 3,149,128 0% 7.7% $59,235,098
Siren, L.L.C. 4.9% 2,202,514 0% 1.6% $41,429,288
VANGUARD GROUP INC 3.4% 1,518,757 +7.4% 0% $28,567,819
BlackRock, Inc. 3.3% 1,459,795 +5% 0% $27,458,744
GOLDMAN SACHS GROUP INC 3.3% 1,454,720 +2.7% 0% $27,363,283
Avoro Capital Advisors LLC 3% 1,337,500 +8.1% 0.33% $25,158,375
ADAR1 Capital Management, LLC 2.6% 1,176,491 +39% 2.2% $22,129,796
VR ADVISER, LLC 1.4% 610,808 +13% 0.65% $11,489,298
Casdin Capital, LLC 1.2% 553,268 0% 0.87% $10,406,971
GEODE CAPITAL MANAGEMENT, LLC 1.2% 545,701 +12% 0% $10,266,005
PERCEPTIVE ADVISORS LLC 1.2% 541,450 0% 0.3% $10,184,675
STATE STREET CORP 0.94% 418,960 +13% 0% $7,880,638
MILLENNIUM MANAGEMENT LLC 0.86% 384,200 +640% 0.01% $7,226,802
Catalio Capital Management, LP 0.66% 294,360 0% 1% $5,536,912
Checkpoint Capital L.P. 0.64% 283,158 -52% 1.8% $5,326,202
Woodline Partners LP 0.63% 282,585 0% 0.03% $5,315,424
Universal- Beteiligungs- und Servicegesellschaft mbH 0.5% 222,702 0% 0.01% $4,189,025
Sio Capital Management, LLC 0.42% 189,199 -68% 0.9% $3,558,833
CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.42% 186,904 +21% 0% $3,515,664
Invesco Ltd. 0.4% 177,070 +1396% 0% $3,330,687

Institutional Holders of Septerna, Inc. - Common Stock (SEPN) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 1,240 $34,571 +$4,879 $27.88 3
2025 Q3 44,549,033 $837,968,810 +$6,406,562 $18.81 82
2025 Q2 44,430,464 $469,630,218 -$8,199,245 $10.57 89
2025 Q1 45,290,316 $262,246,715 -$67,734,091 $5.79 69
2024 Q4 44,129,388 $1,010,571,813 +$770,183,846 $22.90 71