| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Prosight Management, LP | 9.9% | $15,638,344 | 6,543,240 | Prosight Management, LP | 30 Sep 2025 | |||
| Redmile Group, LLC | 9.9% | -16% | $6,379,095 | +$726,435 | 6,379,095 | +13% | Redmile Group, LLC | 25 Aug 2025 |
| ORBIMED ADVISORS LLC | 10% | $6,306,127 | 6,306,127 | ORBIMED ADVISORS LLC | 25 Aug 2025 | |||
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 9.8% | $4,254,250 | 4,675,000 | Adage Capital Management, L.P. | 31 Dec 2024 | |||
| VANGUARD GROUP INC | 4.5% | $2,062,247 | 2,148,174 | The Vanguard Group | 30 Jun 2025 | |||
| BlackRock, Inc. | 1.8% | $843,604 | 878,754 | BlackRock, Inc. | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 9.5% | 6,306,127 | 0.36% | $15,071,644 | |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 9.5% | 6,306,127 | +35% | 0.02% | $15,071,644 |
| Redmile Group, LLC | 8.4% | 5,539,724 | 0% | 1.3% | $13,239,940 |
| Prosight Management, LP | 8.2% | 5,451,195 | -18% | 3.1% | $13,028,356 |
| VANGUARD GROUP INC | 3.2% | 2,128,401 | -0.92% | 0% | $5,086,878 |
| 683 Capital Management, LLC | 2.3% | 1,532,216 | +40% | 0.33% | $3,661,996 |
| CLARK ESTATES INC/NY | 2.2% | 1,475,648 | 0% | 0.81% | $3,526,799 |
| PINNACLE ASSOCIATES LTD | 2.1% | 1,388,723 | +1.8% | 0.04% | $3,319,048 |
| BANK OF AMERICA CORP /DE/ | 1.7% | 1,131,888 | +2968% | 0% | $2,705,212 |
| MILLENNIUM MANAGEMENT LLC | 1% | 690,901 | -18% | 0% | $1,651,253 |
| MARSHALL WACE, LLP | 0.99% | 656,653 | 0% | $1,569,399 | |
| TAKEDA PHARMACEUTICAL CO LTD | 0.78% | 515,619 | 0% | 7.5% | $1,232,329 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.71% | 467,959 | 0% | 0% | $1,118,971 |
| BlackRock, Inc. | 0.62% | 411,292 | -53% | 0% | $982,988 |
| TWO SIGMA INVESTMENTS, LP | 0.62% | 408,598 | +431% | 0% | $976,549 |
| ACADIAN ASSET MANAGEMENT LLC | 0.5% | 329,288 | +26% | 0% | $785,000 |
| RENAISSANCE TECHNOLOGIES LLC | 0.33% | 216,867 | +469% | 0% | $518,312 |
| STATE STREET CORP | 0.27% | 176,718 | 0% | 0% | $422,356 |
| Pathstone Holdings, LLC | 0.24% | 157,083 | -50% | 0% | $375,429 |
| TWO SIGMA ADVISERS, LP | 0.17% | 112,677 | +705% | 0% | $269,298 |
| Bank of New York Mellon Corp | 0.17% | 110,394 | 0% | 0% | $263,842 |
| JANE STREET GROUP, LLC | 0.15% | 99,047 | -66% | 0% | $236,722 |
| Aberdeen Group plc | 0.14% | 94,504 | 0% | $225,865 | |
| NORTHERN TRUST CORP | 0.14% | 91,272 | -18% | 0% | $218,140 |
| LBJ Family Wealth Advisors, Ltd. | 0.12% | 82,177 | 0.11% | $196,000 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 104,809 | $382,606 | +$82,607 | 365.04% | 2 |
| 2025 Q3 | 36,387,666 | $86,952,184 | +$19,207,892 | 239% | 55 |
| 2025 Q2 | 28,683,537 | $22,652,305 | -$2,108,621 | 79.18% | 60 |
| 2025 Q1 | 31,187,405 | $29,628,957 | -$448,909 | 95.01% | 75 |
| 2024 Q4 | 31,630,688 | $38,272,610 | -$6,568,279 | 121% | 73 |
| 2024 Q3 | 34,264,458 | $119,684,045 | +$7,364,713 | 349% | 75 |
| 2024 Q2 | 33,580,085 | $129,618,417 | +$8,634,002 | 386% | 72 |
| 2024 Q1 | 31,464,617 | $281,294,360 | +$22,313,617 | 894% | 68 |
| 2023 Q4 | 2,105,010 | $15,008,722 | +$100,904 | 713% | 2 |
| 2023 Q3 | 19,886,098 | $30,226,948 | -$551,304 | 152% | 39 |
| 2023 Q2 | 20,147,579 | $62,861,356 | +$1,104,302 | 312% | 41 |
| 2023 Q1 | 20,310,101 | $59,710,638 | -$164,775 | 294% | 47 |
| 2022 Q4 | 20,382,396 | $46,879,443 | -$784,859 | 230% | 46 |
| 2022 Q3 | 19,876,509 | $53,662,000 | -$2,691,415 | 269.87% | 61 |
| 2022 Q2 | 21,419,836 | $86,897,063 | -$10,471,216 | 405.89% | 65 |
| 2022 Q1 | 23,972,896 | $102,126,074 | -$3,371,784 | 426% | 74 |
| 2021 Q4 | 22,728,885 | $193,414,464 | -$71,764,466 | 850.99% | 77 |
| 2021 Q3 | 25,772,686 | $525,252,762 | -$13,490,253 | 2,038.08% | 69 |
| 2021 Q2 | 25,886,304 | $750,445,238 | +$70,718,594 | 2,899% | 65 |
| 2021 Q1 | 23,446,586 | $682,659,224 | -$1,540,962 | 2,923.95% | 54 |
| 2020 Q4 | 22,309,276 | $1,151,016,672 | +$1,151,016,997 | 5,240.99% | 58 |