| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 8.1% | $183,878,466 | 3,424,180 | RTW Investments, LP | 30 Jun 2025 | |||
| BlackRock, Inc. | 7.4% | $143,595,686 | 3,092,735 | BlackRock, Inc. | 31 Mar 2025 | |||
| Deep Track Capital, LP | 7.1% | +25% | $178,290,000 | +$38,453,587 | 3,000,000 | +27% | Deep Track Capital, LP | 30 Sep 2025 |
| TANG CAPITAL MANAGEMENT LLC | 5.9% | $113,976,225 | 2,454,797 | TANG CAPITAL MANAGEMENT, LLC | 31 Mar 2025 | |||
| MORGAN STANLEY | 4.7% | $90,234,523 | 1,943,453 | Morgan Stanley | 31 Mar 2025 | |||
| Cowen Financial Products LLC | 4.9% | $88,645,456 | 1,909,228 | Cowen Financial Products LLC | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BlackRock, Inc. | 9% | 3,779,621 | -0.33% | 0% | $224,622,876 |
| RTW INVESTMENTS, LP | 7.5% | 3,177,436 | +2.1% | 2.3% | $188,835,021 |
| Deep Track Capital, LP | 7.1% | 3,000,000 | +71% | 5% | $178,290,000 |
| Paradigm Biocapital Advisors LP | 6.3% | 2,665,698 | -10% | 4.7% | $158,422,432 |
| JENNISON ASSOCIATES LLC | 6.2% | 2,604,580 | +5.5% | 0.09% | $154,790,191 |
| TANG CAPITAL MANAGEMENT LLC | 5.8% | 2,454,797 | 0% | 5.6% | $145,888,586 |
| VANGUARD GROUP INC | 5.4% | 2,272,090 | -1.1% | 0% | $135,030,309 |
| MORGAN STANLEY | 4.5% | 1,912,402 | -7% | 0.01% | $113,654,091 |
| JANUS HENDERSON GROUP PLC | 3.4% | 1,438,999 | -20% | 0.04% | $85,554,237 |
| Assenagon Asset Management S.A. | 3% | 1,247,954 | +25% | 0.11% | $74,165,906 |
| Frazier Life Sciences Management, L.P. | 2.8% | 1,167,527 | -16% | 2.1% | $69,386,130 |
| Driehaus Capital Management LLC | 2.4% | 1,031,041 | +18% | 0.44% | $61,274,767 |
| LORD, ABBETT & CO. LLC | 2.3% | 985,629 | -0.98% | 0.17% | $58,575,000 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.2% | 944,496 | +1.1% | 0% | $56,140,457 |
| Invesco Ltd. | 2.2% | 937,006 | +0.92% | 0.01% | $55,686,267 |
| STATE STREET CORP | 2.2% | 936,162 | -4.6% | 0% | $55,636,108 |
| MACQUARIE GROUP LTD | 2% | 833,437 | -12% | 0.06% | $49,531,000 |
| TORONTO DOMINION BANK | 1.5% | 617,583 | -38% | 0.07% | $36,702,958 |
| D. E. Shaw & Co., Inc. | 1.4% | 598,307 | -17% | 0.03% | $35,557,385 |
| Clearbridge Investments, LLC | 1.3% | 566,978 | +28% | 0.03% | $33,695,506 |
| Artisan Partners Limited Partnership | 1.3% | 558,326 | +3.5% | 0.05% | $33,181,314 |
| BANK OF AMERICA CORP /DE/ | 1.3% | 536,023 | +15% | 0% | $31,855,847 |
| Qube Research & Technologies Ltd | 1.2% | 522,276 | +14% | 0.04% | $31,038,863 |
| Ensign Peak Advisors, Inc | 1.1% | 482,364 | -1% | 0.05% | $28,666,893 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.1% | 452,857 | +18% | 0% | $26,914,000 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 1,141,712 | $93,483,525 | -$9,238,462 | 8,188.63% | 6 |
| 2025 Q3 | 44,886,095 | $2,667,310,850 | -$49,487,109 | 5,943% | 216 |
| 2025 Q2 | 46,131,357 | $1,868,819,935 | +$92,954,247 | 4,051% | 204 |
| 2025 Q1 | 43,564,795 | $2,238,109,529 | +$155,550,094 | 5,137% | 191 |
| 2024 Q4 | 40,257,261 | $2,228,992,174 | -$65,425,290 | 5,537% | 192 |
| 2024 Q3 | 43,391,345 | $1,426,965,026 | +$102,449,516 | 3,289% | 162 |
| 2024 Q2 | 40,069,329 | $1,089,076,999 | +$12,486,301 | 2,718% | 149 |
| 2024 Q1 | 39,163,541 | $1,423,594,819 | +$241,745,001 | 3,635% | 154 |
| 2023 Q4 | 11,442 | $231,701 | +$231,701 | 2,025% | 1 |
| 2023 Q3 | 29,793,106 | $529,411,034 | +$139,188,117 | 1,777% | 105 |
| 2023 Q2 | 21,435,682 | $387,312,182 | +$39,178,152 | 1,807% | 92 |
| 2023 Q1 | 20,057,814 | $252,130,286 | -$6,024,605 | 1,257% | 73 |
| 2022 Q4 | 20,519,699 | $300,819,987 | +$13,982,703 | 1,466% | 65 |
| 2022 Q3 | 20,489,091 | $350,771,070 | +$9,470,918 | 1,712.01% | 72 |
| 2022 Q2 | 19,921,482 | $290,851,823 | +$98,103,713 | 1,460% | 66 |
| 2022 Q1 | 13,199,169 | $222,025,113 | +$2,268,000 | 1,682% | 49 |
| 2021 Q4 | 13,061,832 | $293,966,317 | +$4,706,910 | 2,250% | 42 |
| 2021 Q3 | 12,869,545 | $277,366,450 | -$12,956,592 | 2,155.01% | 44 |
| 2021 Q2 | 13,053,454 | $378,290,053 | -$6,901,273 | 2,898.05% | 43 |
| 2021 Q1 | 12,761,893 | $410,350,129 | -$213,787 | 3,223.08% | 41 |
| 2020 Q4 | 12,759,585 | $523,637,183 | +$523,637,032 | 4,133% | 39 |