| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | 0% | $90,456,313 | +$7,574,932 | 27,662,481 | +9.1% | RA Capital Management, L.P. | 30 Sep 2025 |
| Manning Paul B | 9.8% | $76,803,333 | 25,601,111 | Paul B Manning | 30 May 2025 | |||
| RTW INVESTMENTS, LP | 9.9% | -0.9% | $75,549,861 | +$13,529,940 | 25,183,287 | +22% | RTW Investments, LP | 30 Jun 2025 |
| MORGAN STANLEY | 6.7% | -21% | $39,112,054 | -$1,787,838 | 16,858,644 | -4.4% | Morgan Stanley | 30 Jun 2025 |
| FMR LLC | 6.2% | -22% | $36,256,547 | -$1,711,793 | 15,627,822 | -4.5% | FMR LLC | 30 Jun 2025 |
| BlackRock, Inc. | 5.2% | $30,515,716 | 13,153,326 | BlackRock, Inc. | 30 Jun 2025 | |||
| GOLDMAN SACHS GROUP INC | 5.1% | $29,577,606 | 12,748,968 | THE GOLDMAN SACHS GROUP, INC. | 26 Jun 2025 | |||
| Octagon Capital Advisors LP | 3.3% | -36% | $29,650,725 | -$4,520,775 | 9,067,500 | -13% | Octagon Capital Advisors LP | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 8.9% | 24,354,291 | -2.7% | 0.98% | $79,638,532 |
| RA CAPITAL MANAGEMENT, L.P. | 8.6% | 23,555,648 | 0% | 0.95% | $77,026,969 |
| Avoro Capital Advisors LLC | 7.9% | 21,700,000 | 0% | 0.92% | $70,959,000 |
| MORGAN STANLEY | 7% | 19,307,603 | +14% | 0% | $63,135,862 |
| BlackRock, Inc. | 6% | 16,364,861 | +23% | 0% | $53,513,096 |
| FMR LLC | 5.3% | 14,593,412 | -6.6% | 0% | $47,720,458 |
| GOLDMAN SACHS GROUP INC | 4.9% | 13,383,708 | +6.3% | 0.01% | $43,764,725 |
| VANGUARD GROUP INC | 4.7% | 12,849,613 | +18% | 0% | $42,018,234 |
| Siren, L.L.C. | 4% | 11,014,737 | 0% | 1.4% | $36,018,190 |
| Octagon Capital Advisors LP | 3.3% | 9,067,500 | -28% | 4.6% | $29,650,725 |
| Point72 Asset Management, L.P. | 2.7% | 7,331,470 | +0.19% | 0.05% | $23,973,907 |
| STATE STREET CORP | 2.6% | 7,236,465 | +41% | 0% | $23,663,241 |
| Vestal Point Capital, LP | 2% | 5,500,000 | +83% | 0.82% | $17,985,000 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2% | 5,386,000 | 0% | 0.27% | $17,612,220 |
| Polar Capital Holdings Plc | 1.9% | 5,293,879 | +5.9% | 0.08% | $17,310,984 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.9% | 5,174,516 | +36% | 0% | $16,924,446 |
| BARCLAYS PLC | 1.9% | 5,148,112 | +1043% | 0.01% | $16,834,325 |
| MILLENNIUM MANAGEMENT LLC | 1.5% | 4,026,122 | +37% | 0.01% | $13,165,419 |
| BAKER BROS. ADVISORS LP | 1.5% | 4,004,756 | 0% | 0.09% | $13,095,552 |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 1.3% | 3,700,000 | -9.6% | 39% | $12,099,000 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.2% | 3,328,000 | -31% | 0.02% | $10,882,560 |
| Affinity Asset Advisors, LLC | 1.1% | 3,000,000 | +1400% | 0.91% | $9,810,000 |
| ADAR1 Capital Management, LLC | 1% | 2,835,680 | -5.8% | 0.92% | $9,272,674 |
| D. E. Shaw & Co., Inc. | 0.98% | 2,706,434 | +574% | 0.01% | $8,850,039 |
| Jefferies Financial Group Inc. | 0.78% | 2,156,642 | -79% | 0.06% | $7,052,219 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 781,780 | $4,299,683 | +$4,118,331 | $5.50 | 3 |
| 2025 Q3 | 264,427,699 | $864,676,435 | +$29,348,999 | $3.27 | 150 |
| 2025 Q2 | 257,684,976 | $595,324,582 | +$211,768,583 | $2.31 | 147 |
| 2025 Q1 | 166,761,354 | $231,855,054 | -$5,171,832 | $1.39 | 124 |
| 2024 Q4 | 167,089,013 | $289,098,804 | +$18,983,328 | $1.73 | 125 |
| 2024 Q3 | 156,893,147 | $315,364,730 | -$17,625,139 | $2.01 | 114 |
| 2024 Q2 | 158,086,076 | $354,139,421 | +$33,922,199 | $2.24 | 102 |
| 2024 Q1 | 140,089,173 | $401,959,511 | +$19,199,179 | $2.87 | 105 |
| 2023 Q4 | 130,129,882 | $230,288,972 | -$12,408,685 | $1.77 | 85 |
| 2023 Q3 | 129,862,060 | $410,364,849 | +$376,273,584 | $3.16 | 61 |
| 2023 Q2 | 13,698,356 | $9,051,371 | -$2,014,690 | $0.6610 | 37 |
| 2023 Q1 | 16,687,605 | $13,286,354 | -$3,025,812 | $0.7976 | 42 |
| 2022 Q4 | 19,375,255 | $43,785,515 | +$11,947,434 | $2.26 | 51 |
| 2022 Q3 | 12,891,725 | $25,021,000 | -$1,790,730 | $1.93 | 47 |
| 2022 Q2 | 14,629,559 | $54,431,000 | -$11,130,128 | $3.72 | 53 |
| 2022 Q1 | 16,839,266 | $109,746,239 | -$16,441,631 | $6.52 | 68 |
| 2021 Q4 | 18,273,544 | $212,886,592 | -$15,463,883 | $11.65 | 60 |
| 2021 Q3 | 19,436,846 | $361,910,267 | +$2,739,579 | $18.62 | 48 |
| 2021 Q2 | 18,320,631 | $388,396,891 | +$15,024,022 | $21.20 | 48 |
| 2021 Q1 | 17,661,042 | $358,518,075 | -$11,638,282 | $20.30 | 46 |
| 2020 Q4 | 16,933,973 | $446,962,635 | +$34,062,857 | $26.54 | 49 |
| 2020 Q3 | 16,580,732 | $366,712,000 | +$366,712,047 | $22.40 | 46 |