| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 15% | +37% | $14,143,225 | +$4,500,000 | 7,857,347 | +47% | Lynx1 Capital Management LP | 30 Jun 2025 |
| BIOTECHNOLOGY VALUE FUND L P | 10% | $6,684,697 | 5,263,541 | BVF PARTNERS L P/IL | 31 Mar 2025 | |||
| K2 HealthVentures Equity Trust LLC | 6.9% | $4,575,429 | 3,602,700 | K2 HealthVentures Equity Trust LLC | 31 Dec 2024 | |||
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 7.1% | $4,445,000 | 3,500,000 | Adage Capital Management, L.P. | 31 Dec 2024 | |||
| Adage Capital Management, L.P. | 2.5% | $1,957,500 | 1,350,000 | Adage Capital Management, L.P. | 30 Jun 2025 | |||
| BlackRock, Inc. | 1.8% | -72% | $1,274,636 | -$2,483,708 | 958,373 | -66% | BlackRock, Inc. | 30 Jun 2025 |
| EcoR1 Capital, LLC | 1.3% | $841,798 | 662,833 | EcoR1 Capital, LLC | 31 Mar 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 15% | 7,857,347 | 0% | 2.9% | $14,300,372 |
| BVF INC/IL | 10% | 5,226,074 | 0% | 0.39% | $9,511,455 |
| BAKER BROS. ADVISORS LP | 5.3% | 2,784,792 | 0% | 0.04% | $5,068,321 |
| BlackRock, Inc. | 4.5% | 2,382,764 | -7.2% | 0% | $4,336,629 |
| VANGUARD GROUP INC | 4.4% | 2,317,916 | +7.8% | 0% | $4,218,607 |
| Propel Bio Management, LLC | 3.7% | 1,932,304 | -7.4% | 3.5% | $3,516,793 |
| Aberdeen Group plc | 2.6% | 1,354,820 | +52% | 0% | $2,465,772 |
| Deer Management Co. LLC | 2.4% | 1,245,504 | 0% | 0.2% | $2,266,817 |
| Alphabet Inc. | 2.1% | 1,077,080 | 0% | 0.08% | $1,960,286 |
| Simplify Asset Management Inc. | 1.7% | 904,972 | -14% | 0.03% | $1,647,049 |
| MORGAN STANLEY | 1.6% | 847,537 | -0.68% | 0% | $1,542,518 |
| RENAISSANCE TECHNOLOGIES LLC | 1.6% | 829,919 | +4.8% | 0% | $1,510,453 |
| DC Funds, LP | 1.2% | 630,000 | 0% | 37% | $1,146,600 |
| TANG CAPITAL MANAGEMENT LLC | 1.1% | 600,000 | 0% | 0.04% | $1,092,000 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.1% | 567,657 | +0.23% | 0% | $1,033,532 |
| MILLENNIUM MANAGEMENT LLC | 0.89% | 466,086 | -26% | 0% | $848,277 |
| TWO SIGMA INVESTMENTS, LP | 0.8% | 419,404 | +15% | 0% | $763,315 |
| CITADEL ADVISORS LLC | 0.75% | 390,747 | +78% | 0% | $711,160 |
| TWO SIGMA ADVISERS, LP | 0.55% | 288,800 | +35% | 0% | $525,616 |
| JPMORGAN CHASE & CO | 0.45% | 237,750 | -17% | 0% | $432,705 |
| BANK OF AMERICA CORP /DE/ | 0.43% | 223,024 | +2.3% | 0% | $405,903 |
| STATE STREET CORP | 0.38% | 197,313 | -1.6% | 0% | $359,110 |
| BROWN BROTHERS HARRIMAN & CO | 0.27% | 143,051 | 0% | 0% | $260,353 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0.27% | 140,400 | -8.7% | 0.01% | $255,528 |
| GOLDMAN SACHS GROUP INC | 0.25% | 130,980 | -70% | 0% | $238,383 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 0 | $0 | -$17 | 0 | |
| 2025 Q3 | 34,601,160 | $62,910,264 | -$1,894,620 | $1.82 | 72 |
| 2025 Q2 | 35,724,879 | $51,820,655 | -$5,881,536 | $1.45 | 79 |
| 2025 Q1 | 40,135,840 | $55,390,189 | -$2,855,485 | $1.38 | 92 |
| 2024 Q4 | 41,512,999 | $126,202,372 | -$5,946,742 | $3.04 | 87 |
| 2024 Q3 | 41,835,445 | $208,343,784 | +$255,932 | $4.98 | 86 |
| 2024 Q2 | 41,438,662 | $242,462,174 | +$40,505,809 | $5.85 | 78 |
| 2024 Q1 | 34,291,369 | $272,339,183 | +$19,165,614 | $7.94 | 65 |
| 2023 Q4 | 31,912,819 | $186,051,442 | +$7,357,775 | $5.83 | 54 |
| 2023 Q3 | 28,588,231 | $73,195,868 | +$2,177,864 | $2.56 | 32 |
| 2023 Q2 | 27,951,619 | $69,879,871 | +$45,817,227 | $2.50 | 28 |
| 2023 Q1 | 9,651,730 | $20,268,564 | +$609,616 | $2.10 | 27 |
| 2022 Q4 | 9,519,305 | $14,788,379 | -$121,392 | $1.55 | 28 |
| 2022 Q3 | 9,508,092 | $29,003,732 | -$530,732 | $3.05 | 24 |
| 2022 Q2 | 9,682,082 | $30,449,817 | +$1,526,723 | $3.14 | 23 |
| 2022 Q1 | 9,368,530 | $26,232,000 | -$1,531,305 | $2.80 | 23 |
| 2021 Q4 | 9,861,945 | $44,380,000 | -$2,457,430 | $4.50 | 28 |
| 2021 Q3 | 10,134,939 | $83,484,000 | +$83,484,012 | $8.34 | 26 |