| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Vivo Opportunity Fund Holdings, L.P. | 10% | $26,593,344 | 6,096,175 | Vivo Opportunity Fund Holdings, L.P. | 30 Sep 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | $8,551,111 | 1,960,230 | RA Capital Management, L.P. | 30 Sep 2025 | |||
| BIOTECHNOLOGY VALUE FUND L P | 10% | $6,022,747 | 1,417,117 | BVF PARTNERS L P/IL | 30 Jun 2025 | |||
| Octagon Capital Advisors LP | 5.7% | -26% | $4,362,300 | 1,000,000 | 0% | Octagon Capital Advisors LP | 30 Sep 2025 | |
| GREAT POINT PARTNERS LLC | 4.5% | -29% | $3,474,825 | 796,558 | 0% | Great Point Partners, LLC | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Vivo Capital, LLC | 10% | 1,789,916 | +57% | 0.63% | $7,804,034 |
| Octagon Capital Advisors LP | 5.7% | 1,000,000 | 0% | 0.68% | $4,360,000 |
| Nantahala Capital Management, LLC | 5.4% | 939,202 | 0% | 0.25% | $4,094,921 |
| GREAT POINT PARTNERS LLC | 4.5% | 796,558 | 0% | 1.4% | $3,472,993 |
| VANGUARD GROUP INC | 3.8% | 658,878 | +8.7% | 0% | $2,872,708 |
| Logos Global Management LP | 2.7% | 473,563 | +0% | 0.2% | $2,064,735 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.72% | 125,727 | +114% | 0% | $548,168 |
| Squarepoint Ops LLC | 0.67% | 117,327 | 0% | $511,546 | |
| ACUTA CAPITAL PARTNERS, LLC | 0.34% | 59,985 | -4.6% | 0.27% | $261,535 |
| STATE STREET CORP | 0.31% | 54,827 | +338% | 0% | $239,046 |
| GOLDMAN SACHS GROUP INC | 0.26% | 45,200 | 0% | $197,072 | |
| CITADEL ADVISORS LLC | 0.24% | 41,674 | 0% | $181,699 | |
| XTX Topco Ltd | 0.22% | 37,823 | 0.01% | $164,908 | |
| BlackRock, Inc. | 0.21% | 36,355 | 0% | $158,508 | |
| NORTHERN TRUST CORP | 0.19% | 32,699 | +203% | 0% | $142,568 |
| Chicago Partners Investment Group LLC | 0.15% | 26,961 | 0% | $127,256 | |
| Cubist Systematic Strategies, LLC | 0.14% | 23,947 | 0% | $104,409 | |
| MORGAN STANLEY | 0.06% | 10,612 | +961% | 0% | $46,268 |
| CITIGROUP INC | 0.04% | 6,692 | 0% | $29,177 | |
| UBS Group AG | 0.03% | 5,445 | 0% | $23,740 | |
| BANK OF AMERICA CORP /DE/ | 0% | 827 | +1192% | 0% | $3,606 |
| SBI Securities Co., Ltd. | 0% | 560 | +1.3% | 0% | $2,442 |
| Rockefeller Capital Management L.P. | 0% | 500 | 0% | $2,180 | |
| TFC Financial Management, Inc. | 0% | 300 | 0% | $1,308 | |
| Fortitude Family Office, LLC | 0% | 107 | 0% | $467 |