| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 14% | -8% | $13,162,175 | -$129,035 | 6,681,307 | -0.97% | RA Capital Management, L.P. | 04 Nov 2025 |
| MPM BioVentures 2014, L.P. | 8.2% | -18% | $3,619,627 | -$809,653 | 3,977,612 | -18% | ANSBERT GADICKE | 22 Dec 2025 |
| PFM Health Sciences, LP | 0.9% | -80% | $533,476 | -$3,330,792 | 401,110 | -86% | PFM Health Sciences, LP | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 14% | 6,681,307 | 0% | 0.16% | $13,162,175 |
| MPM ASSET MANAGEMENT LLC | 8.9% | 4,309,860 | 0% | 19% | $8,490,424 |
| MPM BIOIMPACT LLC | 5% | 2,408,810 | 0% | 0.78% | $4,745,356 |
| BANK OF AMERICA CORP /DE/ | 3.8% | 1,830,292 | -14% | 0% | $3,605,675 |
| VANGUARD GROUP INC | 2.9% | 1,408,047 | +8.5% | 0% | $2,773,852 |
| SPHERA FUNDS MANAGEMENT LTD. | 1.3% | 626,810 | 0% | 0.29% | $1,234,816 |
| DC Funds, LP | 1.2% | 589,102 | 0% | 37% | $1,160,531 |
| RENAISSANCE TECHNOLOGIES LLC | 0.94% | 456,000 | +44% | 0% | $898,320 |
| PFM Health Sciences, LP | 0.83% | 401,110 | 0% | 0.07% | $790,187 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.68% | 330,787 | +0.86% | 0% | $651,832 |
| MILLENNIUM MANAGEMENT LLC | 0.65% | 317,053 | -54% | 0% | $624,594 |
| JANE STREET GROUP, LLC | 0.55% | 268,577 | -28% | 0% | $529,097 |
| Alyeska Investment Group, L.P. | 0.49% | 235,705 | 0% | 0% | $464,339 |
| CITADEL ADVISORS LLC | 0.32% | 154,534 | 0% | $304,432 | |
| STATE STREET CORP | 0.25% | 119,168 | 0% | 0% | $234,761 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0.21% | 102,000 | 0% | 0% | $200,940 |
| BlackRock, Inc. | 0.21% | 101,323 | -72% | 0% | $199,606 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.19% | 93,041 | +17% | 0% | $183,291 |
| NORTHERN TRUST CORP | 0.14% | 65,836 | 0% | 0% | $129,697 |
| GOLDMAN SACHS GROUP INC | 0.12% | 60,341 | -73% | 0% | $118,872 |
| EDGEWOOD MANAGEMENT LLC | 0.1% | 50,000 | 0% | 0% | $98,500 |
| Cubist Systematic Strategies, LLC | 0.1% | 46,711 | 0% | $92,020 | |
| HRT FINANCIAL LP | 0.08% | 39,859 | -6.2% | 0% | $78,000 |
| Vontobel Holding Ltd. | 0.07% | 36,000 | -10% | 0% | $70,920 |
| TWO SIGMA ADVISERS, LP | 0.07% | 34,600 | -39% | 0% | $68,162 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 21,108,242 | $41,572,612 | -$2,126,396 | 197% | 62 |
| 2025 Q2 | 22,335,758 | $24,343,246 | -$5,335,454 | 109% | 65 |
| 2025 Q1 | 27,445,533 | $26,679,067 | -$940,149 | 97.22% | 70 |
| 2024 Q4 | 28,168,571 | $41,689,237 | -$7,798,202 | 148% | 70 |
| 2024 Q3 | 32,205,548 | $68,274,294 | -$1,019,969 | 212% | 68 |
| 2024 Q2 | 32,236,039 | $78,650,636 | -$5,841,249 | 244% | 69 |
| 2024 Q1 | 32,250,885 | $208,967,732 | +$29,727,953 | 648% | 58 |
| 2023 Q4 | 27,669,999 | $106,805,060 | +$14,930,496 | 386% | 41 |
| 2023 Q3 | 23,882,934 | $51,107,776 | -$364,729 | 214% | 34 |
| 2023 Q2 | 24,044,510 | $73,333,928 | +$109,395 | 305% | 35 |
| 2023 Q1 | 24,035,818 | $62,491,910 | +$8,495,816 | 260% | 37 |
| 2022 Q4 | 20,880,228 | $42,804,090 | -$4,165,821 | 205% | 36 |
| 2022 Q3 | 20,956,559 | $94,490,128 | +$8,516,084 | 451.01% | 39 |
| 2022 Q2 | 19,049,454 | $77,912,023 | +$211,265 | 409% | 37 |
| 2022 Q1 | 18,982,797 | $83,522,100 | -$5,018,445 | 440% | 47 |
| 2021 Q4 | 19,095,808 | $227,430,761 | -$994,747 | 1,191% | 49 |
| 2021 Q3 | 19,007,939 | $326,228,290 | -$12,882,776 | 1,716% | 42 |
| 2021 Q2 | 19,758,281 | $344,315,360 | +$334,041,398 | 1,744% | 45 |