| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 16% | -9.4% | $93,159,037 | -$8,968,497 | 11,130,112 | -8.8% | BlackRock, Inc. | 31 Mar 2025 |
| PRIMECAP MANAGEMENT CO/CA/ | 15% | $84,744,942 | 10,527,322 | PRIMECAP MANAGEMENT CO/CA/ | 30 Jun 2025 | |||
| VANGUARD GROUP INC | 10% | +0.8% | $105,464,036 | +$967,756 | 7,169,547 | +0.93% | The Vanguard Group | 28 Nov 2025 |
| RTW INVESTMENTS, LP | 8.7% | $72,972,963 | 6,221,054 | RTW Investments, LP | 30 Sep 2025 | |||
| BIOTECHNOLOGY VALUE FUND L P | 6.5% | $54,184,870 | 4,619,341 | BVF PARTNERS L P/IL | 09 Oct 2025 | |||
| STATE STREET CORP | 5.2% | $30,832,695 | 3,683,715 | STATE STREET CORPORATION | 31 Mar 2025 | |||
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.4% | $19,862,315 | 1,693,292 | T. Rowe Price Associates, Inc. | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BlackRock, Inc. | 17% | 11,807,227 | -0.41% | 0% | $138,498,772 |
| PRIMECAP MANAGEMENT CO/CA/ | 15% | 10,675,022 | +1.4% | 0.1% | $125,218,008 |
| VANGUARD GROUP INC | 9.9% | 7,103,758 | -18% | 0% | $83,327,080 |
| RTW INVESTMENTS, LP | 8.7% | 6,221,054 | +159% | 0.9% | $72,972,963 |
| EcoR1 Capital, LLC | 8.6% | 6,144,767 | 0% | 3.5% | $72,078,117 |
| STATE STREET CORP | 5.1% | 3,673,831 | -3.8% | 0% | $43,094,038 |
| BVF INC/IL | 3.8% | 2,740,141 | 0% | 1.3% | $32,141,854 |
| TCG Crossover Management, LLC | 3.4% | 2,452,138 | 0% | 1.4% | $28,763,579 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.4% | 1,728,825 | +1.5% | 0% | $20,282,231 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.4% | 1,693,292 | -55% | 0% | $19,863,000 |
| DIMENSIONAL FUND ADVISORS LP | 2.2% | 1,588,963 | -11% | 0% | $18,637,575 |
| Legal & General Group Plc | 1.8% | 1,273,000 | +604% | 0% | $14,932,290 |
| BRAIDWELL LP | 1.7% | 1,246,280 | -25% | 0.43% | $14,618,864 |
| UBS Group AG | 1.6% | 1,175,267 | +51% | 0% | $13,785,882 |
| BAKER BROS. ADVISORS LP | 1.5% | 1,102,106 | +64% | 0.09% | $12,927,703 |
| Nantahala Capital Management, LLC | 1.5% | 1,100,000 | +34% | 0.8% | $12,903,000 |
| GOLDMAN SACHS GROUP INC | 1.4% | 1,017,453 | +42% | 0% | $11,934,724 |
| MORGAN STANLEY | 1.3% | 900,837 | -12% | 0% | $10,566,819 |
| TWO SIGMA ADVISERS, LP | 1.1% | 810,200 | +40% | 0.02% | $9,503,646 |
| BANK OF AMERICA CORP /DE/ | 1.1% | 753,829 | -20% | 0% | $8,842,414 |
| JOHNSON & JOHNSON | 1% | 748,062 | 0% | 1.7% | $8,774,767 |
| NORTHERN TRUST CORP | 1% | 712,201 | -0.51% | 0% | $8,354,119 |
| MILLENNIUM MANAGEMENT LLC | 0.98% | 702,574 | +103% | 0.01% | $8,241,193 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.96% | 688,269 | +15% | 0% | $8,073,395 |
| TWO SIGMA INVESTMENTS, LP | 0.88% | 629,376 | +43% | 0.01% | $7,382,580 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 169,936 | $2,582,083 | +$553,318 | $15.31 | 8 |
| 2025 Q3 | 81,939,553 | $960,205,199 | +$5,937,774 | $11.73 | 202 |
| 2025 Q2 | 82,284,537 | $646,977,988 | +$20,020,529 | $7.86 | 191 |
| 2025 Q1 | 78,656,178 | $836,867,952 | +$36,707,487 | $10.64 | 197 |
| 2024 Q4 | 74,962,874 | $1,722,861,331 | +$79,537,443 | $22.98 | 191 |
| 2024 Q3 | 71,882,419 | $1,445,872,270 | +$169,399,287 | $20.11 | 208 |
| 2024 Q2 | 63,681,713 | $1,205,498,006 | -$22,148,649 | $18.93 | 197 |
| 2024 Q1 | 64,621,378 | $1,429,959,794 | +$31,162,259 | $22.13 | 198 |
| 2023 Q4 | 454,750 | $9,660,461 | +$3,641,408 | $21.23 | 4 |
| 2023 Q3 | 62,658,648 | $1,262,565,901 | +$11,703,524 | $20.15 | 171 |
| 2023 Q2 | 62,015,119 | $1,549,346,178 | -$36,172,737 | $24.97 | 176 |
| 2023 Q1 | 63,367,351 | $1,765,610,205 | +$59,902,633 | $27.89 | 181 |
| 2022 Q4 | 61,300,583 | $1,596,161,663 | +$18,318,746 | $26.04 | 190 |
| 2022 Q3 | 59,315,978 | $1,541,598,412 | -$68,962,901 | $25.98 | 168 |
| 2022 Q2 | 59,660,303 | $1,633,193,757 | +$21,072,856 | $27.37 | 164 |
| 2022 Q1 | 58,237,069 | $1,554,126,624 | -$2,657,016 | $26.68 | 166 |
| 2021 Q4 | 58,987,922 | $2,365,381,492 | +$29,101,766 | $40.12 | 168 |
| 2021 Q3 | 58,010,746 | $1,895,262,645 | -$1,450,797 | $32.66 | 165 |
| 2021 Q2 | 57,076,217 | $1,967,937,118 | -$22,957,334 | $34.49 | 170 |
| 2021 Q1 | 58,342,740 | $2,511,496,329 | -$26,226,685 | $43.06 | 164 |
| 2020 Q4 | 58,929,031 | $2,571,803,029 | +$183,337 | $43.63 | 166 |
| 2020 Q3 | 58,236,243 | $2,259,134,763 | +$12,043,209 | $38.79 | 153 |
| 2020 Q2 | 58,029,899 | $1,879,622,338 | +$194,449,929 | $32.39 | 145 |
| 2020 Q1 | 52,069,345 | $1,555,840,879 | -$40,750,940 | $29.88 | 134 |
| 2019 Q4 | 53,356,223 | $1,834,903,044 | -$10,046,517 | $34.39 | 158 |
| 2019 Q3 | 53,516,552 | $1,805,186,465 | +$147,572,033 | $33.73 | 147 |
| 2019 Q2 | 48,691,275 | $1,992,873,677 | +$84,996,511 | $40.93 | 116 |
| 2019 Q1 | 47,884,863 | $1,487,301,921 | +$4,003,959 | $31.06 | 114 |
| 2018 Q4 | 47,683,292 | $1,723,908,659 | +$32,122,532 | $36.16 | 114 |
| 2018 Q3 | 46,792,024 | $1,822,657,724 | +$3,364,938 | $38.97 | 122 |
| 2018 Q2 | 46,235,548 | $1,711,133,538 | +$99,021,314 | $37.01 | 118 |
| 2018 Q1 | 44,489,188 | $1,333,778,581 | +$227,037,577 | $29.98 | 119 |
| 2017 Q4 | 37,368,317 | $819,140,426 | +$3,648,828 | $21.92 | 103 |
| 2017 Q3 | 37,051,552 | $849,132,220 | +$8,824,104 | $22.92 | 103 |
| 2017 Q2 | 36,802,910 | $776,900,692 | +$21,712,439 | $21.11 | 112 |
| 2017 Q1 | 35,614,184 | $851,874,478 | +$81,468,705 | $23.92 | 123 |
| 2016 Q4 | 34,985,217 | $920,762,537 | +$142,704,482 | $26.32 | 135 |
| 2016 Q3 | 29,626,637 | $724,863,086 | +$38,508,297 | $24.49 | 120 |
| 2016 Q2 | 28,076,434 | $533,154,236 | +$3,625,978 | $18.99 | 97 |
| 2016 Q1 | 27,816,744 | $373,257,000 | +$23,915,380 | $13.42 | 88 |
| 2015 Q4 | 26,171,247 | $382,476,117 | -$18,697,560 | $14.62 | 92 |
| 2015 Q3 | 27,657,914 | $338,268,935 | +$37,620,209 | $12.23 | 91 |
| 2015 Q2 | 25,032,656 | $549,967,155 | +$72,654,118 | $21.97 | 96 |
| 2015 Q1 | 21,170,284 | $324,328,260 | +$126,248,865 | $15.32 | 93 |
| 2014 Q4 | 12,720,419 | $203,458,985 | +$5,070,237 | $16.04 | 62 |
| 2014 Q3 | 13,435,605 | $124,719,599 | +$3,614,968 | $9.31 | 50 |
| 2014 Q2 | 11,779,741 | $136,878,713 | -$5,227,942 | $11.62 | 50 |
| 2014 Q1 | 14,971,172 | $175,611,000 | +$18,263,134 | $11.73 | 42 |