MeiraGTx Holdings plc - Ordinary Shares, nominal value $0.00003881 per share (MGTX) Institutional Ownership

13F Institutional Holders and Ownership History from Q2 2018 to Q4 2025

Type / Class: Equity / Ordinary Shares, nominal value $0.00003881 per share
Symbol: MGTX on Nasdaq
Shares outstanding: 80,942,341
Price per share: $7.95
All holders as of 30 Sep 2025: Q3 2025
Total 13F shares: 64,091,394
Total reported value: $527,366,098
% of total 13F portfolios: 0%
Share change: -162,182
Value change: +$100,847
Number of holders: 121
Price from insider filings: $7.95

Reported Shares, Excluding Options vs Price

Reported Value, Excluding Options

Total Investors

Significant Owners of MeiraGTx Holdings plc - Ordinary Shares, nominal value $0.00003881 per share (MGTX) based on Schedule 13D/G filings

Filer	Ownership	Holdings Value	Nb Shares	Reporting Name	Report Period
PERCEPTIVE ADVISORS LLC	13%	$85,934,055	10,441,562	Perceptive Advisors LLC	31 Dec 2025
Prosight Management, LP	5.4%	$22,087,815	4,356,571	W. Lawrence Hawkins	31 Mar 2025
Adage Capital Management, L.P.	5.2%	$34,441,169	4,184,578	Adage Capital Management, L.P.	30 Sep 2025

As of 30 Sep 2025, 121 institutional investors reported holding 64,091,394 shares of MeiraGTx Holdings plc - Ordinary Shares, nominal value $0.00003881 per share (MGTX). This represents 79% of the company’s total 80,942,341 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of MeiraGTx Holdings plc - Ordinary Shares, nominal value $0.00003881 per share (MGTX) together control 75% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution	Ownership %	Shares Held	Share Change %	Portfolio %	Holdings Value
PERCEPTIVE ADVISORS LLC	16%	12,626,103	0%	3%	$103,792,540
Sanofi	15%	12,197,737	0%	39%	$100,387,376
JOHNSON & JOHNSON	8.2%	6,641,064	0%	11%	$54,655,957
ADAGE CAPITAL PARTNERS GP, L.L.C.	5.2%	4,184,578	-31%	0.05%	$34,439,077
Prosight Management, LP	5.1%	4,089,509	-11%	8.1%	$33,656,659
Rubric Capital Management LP	4.6%	3,726,451	0%	0.41%	$30,668,692
BlackRock, Inc.	3.4%	2,774,272	-3.1%	0%	$22,832,257
683 Capital Management, LLC	3.2%	2,625,000	-2.4%	2%	$21,603,749
MILLENNIUM MANAGEMENT LLC	3.2%	2,560,969	+226%	0.02%	$21,076,775
J. Goldman & Co LP	2.2%	1,800,931	-12%	0.56%	$14,821,662
Knoll Capital Management, LLC	1.5%	1,250,000	0%	5.5%	$10,287,500
MORGAN STANLEY	1.5%	1,241,994	+173%	0%	$10,221,611
Erste Asset Management GmbH	0.88%	709,702	-10%	0.06%	$5,855,042
STATE STREET CORP	0.84%	681,031	-0.17%	0%	$5,604,885
22NW, LP	0.72%	586,519	0%	2.5%	$4,827,051
GEODE CAPITAL MANAGEMENT, LLC	0.69%	555,313	-0.4%	0%	$4,570,225
Long Focus Capital Management, LLC	0.65%	524,745	0%	0.25%	$4,318,651
VANGUARD GROUP INC	0.57%	463,935	+10%	0%	$3,818,185
ROYAL BANK OF CANADA	0.37%	300,343	-1.2%	0%	$2,471,000
NORTHERN TRUST CORP	0.33%	270,893	-1.1%	0%	$2,229,450
GOLDMAN SACHS GROUP INC	0.32%	260,219	+78%	0%	$2,141,602
CITADEL ADVISORS LLC	0.25%	204,865	+1.6%	0%	$1,686,039
Woodline Partners LP	0.25%	200,323		0.01%	$1,648,658
BANK OF AMERICA CORP /DE/	0.24%	198,206	-26%	0%	$1,631,235
D. E. Shaw & Co., Inc.	0.21%	173,202		0%	$1,425,453

Institutional Holders of MeiraGTx Holdings plc - Ordinary Shares, nominal value $0.00003881 per share (MGTX) across Reporting Periods

Period	Reported Shares, Excl. Options	Value, Excl. Options	Value Change	Puts Notional Value	Calls Notional Value	Price (Median)	Investors
2025 Q4	94,229	$749,382	+$50,655			$7.95	5
2025 Q3	64,091,394	$527,366,098	+$100,847	$511,083	$476,517	$8.23	121
2025 Q2	64,273,449	$419,562,716	+$27,529,428	$88,672	$237,980	$6.52	111
2025 Q1	59,986,380	$406,654,896	+$13,171,913	$260,352	$1,078,020	$6.78	118
2024 Q4	58,102,753	$353,684,131	+$5,648,256	$187,572	$1,657,698	$6.09	100
2024 Q3	45,221,185	$188,552,114	+$19,157,175	$129,270	$80,064	$4.17	97
2024 Q2	40,458,048	$170,235,533	+$4,338,226	$129,247	$101,882	$4.21	91
2024 Q1	39,300,424	$238,470,052	+$806,900	$126,863	$20,031	$6.07	95
2023 Q4	743,757	$5,223,294	+$1,641,111			$7.02	3
2023 Q3	37,295,717	$183,122,524	+$956,123	$137,971	$70,213	$4.91	73
2023 Q2	37,053,131	$248,995,980	+$61,045,970	$198,912	$61,152	$6.72	76
2023 Q1	28,332,244	$146,466,827	-$5,267,059	$91,509	$133,386	$5.17	87
2022 Q4	29,197,860	$190,326,188	+$4,534,062	$279,708	$459,660	$6.52	96
2022 Q3	27,520,776	$230,803,903	-$9,072,746	$645,000	$409,000	$8.41	92
2022 Q2	26,231,269	$198,575,613	-$5,319,148	$182,000	$268,000	$7.57	95
2022 Q1	28,964,398	$401,148,631	+$9,719,444	$386,000	$323,000	$13.85	98
2021 Q4	28,109,745	$666,757,362	+$14,459,841	$1,593,000	$1,373,000	$23.74	91
2021 Q3	27,842,129	$366,986,255	-$2,658,907	$217,000	$0	$13.18	77
2021 Q2	27,968,466	$433,447,019	+$16,614,889	$200,000	$172,000	$15.50	76
2021 Q1	26,264,234	$372,298,966	+$3,072,019	$182,000	$186,000	$14.43	76
2020 Q4	23,803,056	$360,374,585	+$66,175,884			$15.14	87
2020 Q3	22,117,893	$292,849,916	+$16,411,870			$13.24	80
2020 Q2	20,521,494	$256,923,889	+$8,582,924			$12.52	74
2020 Q1	19,811,856	$266,270,711	+$42,790,303			$13.44	78
2019 Q4	16,470,694	$329,741,421	+$15,379,656			$20.02	81
2019 Q3	15,780,839	$251,700,768	+$48,014,283			$15.95	78
2019 Q2	12,687,234	$334,418,503	+$30,513,412			$26.88	66
2019 Q1	11,960,858	$205,057,171	+$83,785,646			$17.23	53
2018 Q4	7,221,313	$69,611,048	+$7,484,488			$9.64	36
2018 Q3	6,408,742	$87,153,000	-$155,487			$13.60	35
2018 Q2	6,512,433	$74,625,000	+$74,625,022			$11.46	23