| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 6.2% | +22% | $440M | $105M | 4.67M | +31.5% | Paradigm BioCapital Advisors LP | Sep 30, 2025 |
| Commodore Capital LP | 4.7% | -13.3% | $237M | -$15.1M | 3.53M | -6% | Commodore Capital LP | Jun 30, 2025 |
| FMR LLC | 3.7% | $262M | 2.78M | FMR LLC | Sep 30, 2025 | |||
| RTW INVESTMENTS, LP | 2.7% | $191M | 2.03M | RTW Investments, LP | Sep 30, 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 0.6% | -88% | $43.2M | -$308M | 459K | -87.7% | Wellington Management Group LLP | Sep 30, 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 69M | $6.5B | -$237M | $94.15 | 259 |
| 2025 Q2 | 74.8M | $3.93B | +$216M | $52.60 | 200 |
| 2025 Q1 | 70.8M | $2.98B | +$29.9M | $42.09 | 185 |
| 2024 Q4 | 70.4M | $2.96B | -$77.8M | $42.05 | 190 |
| 2024 Q3 | 69M | $3.45B | +$63.9M | $49.96 | 187 |
| 2024 Q2 | 66.5M | $3.93B | +$944M | $59.17 | 177 |
| 2024 Q1 | 51.2M | $2.31B | +$5.68M | $45.03 | 157 |
| 2023 Q4 | 149K | $4.1M | +$556K | $27.50 | 3 |
| 2023 Q3 | 47.4M | $1.12B | +$142M | $23.58 | 110 |
| 2023 Q2 | 41.2M | $1.08B | +$131M | $26.33 | 109 |
| 2023 Q1 | 36.5M | $671M | +$1.89M | $18.40 | 102 |
| 2022 Q4 | 36.4M | $564M | -$16.9M | $15.47 | 89 |
| 2022 Q3 | 33.4M | $669M | -$19.9M | $20.03 | 95 |
| 2022 Q2 | 35M | $792M | +$41.6M | $22.64 | 91 |
| 2022 Q1 | 33.2M | $878M | +$399K | $26.44 | 92 |
| 2021 Q4 | 32.6M | $1.04B | +$315M | $31.80 | 101 |
| 2021 Q3 | 22.2M | $488M | -$93.8M | $22.00 | 62 |
| 2021 Q2 | 26.8M | $564M | +$1.57M | $21.07 | 66 |
| 2021 Q1 | 26.7M | $558M | +$113M | $20.89 | 57 |
| 2020 Q4 | 21.3M | $374M | +$61.5M | $17.53 | 41 |
| 2020 Q3 | 18.2M | $218M | -$6.78M | $12.00 | 40 |
| 2020 Q2 | 17.9M | $288M | +$8.15M | $16.09 | 41 |
| 2020 Q1 | 18M | $218M | +$1.72M | $12.10 | 29 |
| 2019 Q4 | 17.8M | $251M | +$61.1M | $14.08 | 38 |
| 2019 Q3 | 11.9M | $212M | +$2.52M | $17.82 | 26 |
| 2019 Q2 | 11.8M | $173M | -$427K | $14.65 | 26 |
| 2019 Q1 | 11.9M | $175M | -$2.84M | $14.77 | 24 |
| 2018 Q4 | 12.1M | $169M | -$3.57M | $14.00 | 25 |
| 2018 Q3 | 12.1M | $238M | -$3.67M | $19.74 | 29 |
| 2018 Q2 | 12.3M | $280M | +$31.2M | $22.76 | 25 |
| 2018 Q1 | 9.8M | $182M | +$39M | $18.53 | 20 |
| 2017 Q4 | 5.7M | $111M | -$2.56M | $19.40 | 16 |
| 2017 Q3 | 5.83M | $116M | -$9.16M | $19.87 | 16 |
| 2017 Q2 | 6.31M | $100M | -$1.09M | $15.85 | 16 |
| 2017 Q1 | 6.34M | $155M | +$36M | $24.38 | 22 |
| 2016 Q4 | 4.86M | $103M | +$2.73M | $21.11 | 11 |
| 2016 Q3 | 4.66M | $78M | +$232K | $16.75 | 11 |
| 2016 Q2 | 4.81M | $38.6M | +$38.6M | $7.99 | 16 |