| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | 0% | $167,274,450 | +$2,837,586 | 11,063,125 | +1.7% | RA Capital Management, L.P. | 31 Mar 2025 |
| Capital World Investors | 8.7% | +15% | $279,357,901 | +$40,811,002 | 9,822,711 | +17% | Capital World Investors | 30 Sep 2025 |
| Forbion Capital Fund IV Cooperatief U.A. | 8.3% | -12% | $223,140,090 | -$30,222,313 | 9,316,914 | -12% | ForGrowth NAP B.V. | 26 Sep 2025 |
| Frazier Life Sciences X, L.P. | 7.7% | +17% | $245,264,825 | +$36,858,297 | 8,623,939 | +18% | Frazier Life Sciences Public Fund, L.P. | 01 Nov 2025 |
| VIKING GLOBAL INVESTORS LP | 6.5% | $105,515,434 | 6,978,534 | VIKING GLOBAL INVESTORS LP | 31 Dec 2024 | |||
| BCLS II Investco, LP | 4.7% | -53% | $214,462,841 | -$241,180,844 | 5,376,356 | -53% | BCLS Fund III Investments, LP | 02 Dec 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 15% | 16,701,956 | +0.57% | 14% | $475,003,629 |
| Bain Capital Life Sciences Investors, LLC | 9.4% | 10,719,110 | 0% | 20% | $304,851,488 |
| RA CAPITAL MANAGEMENT, L.P. | 8.9% | 10,138,938 | 0% | 3.6% | $288,351,397 |
| Capital World Investors | 8.6% | 9,822,711 | +17% | 0.04% | $279,357,901 |
| FCPM III SERVICES B.V. | 8.1% | 9,212,384 | -13% | 52% | $262,000,201 |
| VIKING GLOBAL INVESTORS LP | 5.7% | 6,475,534 | -7.2% | 0.48% | $184,164,187 |
| FMR LLC | 4.8% | 5,535,293 | +191% | 0.01% | $157,423,733 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3.7% | 4,266,693 | -17% | 1.9% | $121,344,749 |
| JENNISON ASSOCIATES LLC | 3.7% | 4,198,554 | +43% | 0.07% | $119,406,877 |
| WELLINGTON MANAGEMENT GROUP LLP | 3.5% | 4,020,126 | +21% | 0.02% | $114,332,383 |
| Polar Capital Holdings Plc | 2.5% | 2,911,634 | +16% | 0.4% | $82,806,871 |
| Medicxi Ventures Management (Jersey) Ltd | 2.5% | 2,869,565 | 0% | 11% | $81,610,429 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2.3% | 2,576,631 | -14% | 0.12% | $73,279,386 |
| Cormorant Asset Management, LP | 1.9% | 2,175,000 | 0% | 4.3% | $61,857,000 |
| ALLIANCEBERNSTEIN L.P. | 1.9% | 2,141,778 | -8.1% | 0.02% | $60,912,166 |
| JANUS HENDERSON GROUP PLC | 1.9% | 2,117,075 | +7.9% | 0.03% | $60,146,101 |
| Capital International Investors | 1.8% | 2,062,535 | 0% | 0.01% | $58,658,495 |
| Duquesne Family Office LLC | 1.7% | 1,923,700 | +131% | 1.4% | $54,710,000 |
| MAVERICK CAPITAL LTD | 1.3% | 1,504,747 | -1.8% | 0.57% | $42,795,005 |
| MORGAN STANLEY | 1.3% | 1,497,479 | +135% | 0% | $42,588,310 |
| JPMORGAN CHASE & CO | 1.1% | 1,302,498 | -11% | 0% | $37,043,043 |
| Pictet Asset Management Holding SA | 1.1% | 1,292,150 | -29% | 0.04% | $36,748,746 |
| Woodline Partners LP | 1% | 1,157,867 | -39% | 0.16% | $32,929,737 |
| GOLDMAN SACHS GROUP INC | 0.77% | 880,552 | -7.3% | 0% | $25,042,899 |
| TimesSquare Capital Management, LLC | 0.73% | 837,368 | -4% | 0.34% | $23,814,746 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 13,374 | $448,520 | +$4,525 | 3,508.71% | 4 |
| 2025 Q3 | 120,390,578 | $3,423,901,851 | +$122,883,175 | 2,844% | 134 |
| 2025 Q2 | 116,368,291 | $2,107,516,504 | +$92,203,096 | 1,811% | 130 |
| 2025 Q1 | 111,177,846 | $2,278,669,708 | +$247,823,358 | 2,047% | 126 |
| 2024 Q4 | 98,611,632 | $2,534,320,573 | +$569,548,987 | 2,570% | 130 |
| 2024 Q3 | 77,090,356 | $1,279,730,929 | +$65,897,506 | 1,660% | 102 |
| 2024 Q2 | 72,012,804 | $1,383,416,997 | -$7,858,040 | 1,921% | 90 |
| 2024 Q1 | 72,152,341 | $1,706,357,479 | +$238,965,320 | 2,365% | 76 |
| 2023 Q4 | 61,897,680 | $691,396,295 | -$380,959 | 1,117% | 32 |
| 2023 Q3 | 50,178,896 | $464,099,871 | +$5,440,465 | 925% | 35 |
| 2023 Q2 | 48,833,993 | $580,635,231 | +$184,129,037 | 1,189% | 29 |
| 2023 Q1 | 33,346,896 | $444,858,187 | +$689,121 | 1,326% | 20 |
| 2022 Q4 | 33,516,836 | $362,234,361 | +$362,234,360 | 1,090% | 14 |