| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 13% | -8% | $195,224,587 | 25,453,010 | 0% | RA Capital Management, L.P. | 11 Dec 2025 | |
| Adage Capital Management, L.P. | 9.6% | +19% | $97,607,250 | +$16,250,000 | 15,016,500 | +20% | Adage Capital Management, L.P. | 30 Jun 2025 |
| BlackRock, Inc. | 6.1% | $57,471,401 | 9,360,163 | BlackRock, Inc. | 31 Dec 2024 | |||
| MAVERICK CAPITAL LTD | 5.4% | $50,724,026 | 8,261,242 | Maverick Capital, Ltd. | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9.6% | 18,202,009 | 0% | 1.6% | $133,238,706 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 7.7% | 14,567,784 | -3% | 0.17% | $106,636,179 |
| BlackRock, Inc. | 5.5% | 10,430,813 | +0.45% | 0% | $76,353,551 |
| MAVERICK CAPITAL LTD | 4.4% | 8,391,856 | +1.6% | 0.82% | $61,428,386 |
| Driehaus Capital Management LLC | 3.3% | 6,298,060 | -3.6% | 0.33% | $46,101,799 |
| M28 Capital Management LP | 3% | 5,664,548 | 0% | 61% | $41,464,491 |
| FMR LLC | 2.7% | 5,130,374 | +729% | 0% | $37,554,335 |
| Kynam Capital Management, LP | 2.4% | 4,560,053 | 0% | 2.5% | $33,379,588 |
| 683 Capital Management, LLC | 2.2% | 4,150,000 | +1.2% | 2.8% | $30,378,001 |
| Bellevue Group AG | 2.2% | 4,094,458 | 0% | 0.62% | $29,971,433 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.1% | 4,044,492 | -22% | 0% | $29,607,000 |
| FEDERATED HERMES, INC. | 2% | 3,750,693 | +678145% | 0.05% | $27,455,073 |
| Siren, L.L.C. | 1.9% | 3,696,322 | 0% | 1.1% | $27,057,077 |
| VANGUARD GROUP INC | 1.7% | 3,139,836 | -9.7% | 0% | $22,983,600 |
| EMERALD ADVISERS, LLC | 1.6% | 2,996,900 | -8% | 0.7% | $21,937,308 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.5% | 2,918,370 | +5.8% | 0% | $21,365,183 |
| LOOMIS SAYLES & CO L P | 1.5% | 2,905,466 | -12% | 0.03% | $21,268,011 |
| STATE STREET CORP | 1.5% | 2,846,366 | +3.3% | 0% | $20,835,399 |
| GOLDMAN SACHS GROUP INC | 1.1% | 2,125,137 | +111% | 0% | $15,556,003 |
| STEMPOINT CAPITAL LP | 1.1% | 2,110,152 | +134% | 3.1% | $15,446,313 |
| Affinity Asset Advisors, LLC | 1.1% | 2,100,000 | +5% | 1.4% | $15,372,000 |
| PRIMECAP MANAGEMENT CO/CA/ | 1% | 1,898,650 | -23% | 0.01% | $13,898,118 |
| Pfizer Inc | 0.99% | 1,875,000 | 0% | 3.1% | $13,725,000 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0.93% | 1,766,062 | -8.8% | 0.67% | $12,927,574 |
| MPM BIOIMPACT LLC | 0.79% | 1,505,262 | 0% | 1.8% | $11,018,518 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 68,189 | $1,159,686 | +$1,138,396 | $17.00 | 4 |
| 2025 Q3 | 143,683,496 | $1,051,664,882 | +$37,209,381 | $7.32 | 187 |
| 2025 Q2 | 138,939,054 | $903,136,388 | +$46,387,739 | $6.50 | 174 |
| 2025 Q1 | 131,293,097 | $1,061,209,500 | +$20,316,386 | $8.08 | 192 |
| 2024 Q4 | 128,600,738 | $1,590,819,737 | +$87,821,907 | $12.37 | 180 |
| 2024 Q3 | 120,131,680 | $985,159,356 | +$175,012,354 | $8.20 | 159 |
| 2024 Q2 | 93,731,221 | $467,718,963 | +$9,889,040 | $4.99 | 142 |
| 2024 Q1 | 92,759,614 | $572,308,125 | -$444,057 | $6.17 | 132 |
| 2023 Q4 | 1,371,684 | $7,694,829 | -$132,177 | $5.34 | 2 |
| 2023 Q3 | 72,598,087 | $417,436,571 | +$2,964,681 | $5.75 | 85 |
| 2023 Q2 | 72,146,788 | $262,613,298 | +$6,600,493 | $3.64 | 79 |
| 2023 Q1 | 70,086,593 | $303,466,627 | +$3,707,268 | $4.33 | 72 |
| 2022 Q4 | 68,108,089 | $476,736,473 | +$7,474,869 | $7.00 | 74 |
| 2022 Q3 | 67,126,427 | $242,328,542 | -$1,791,919 | $3.61 | 56 |
| 2022 Q2 | 67,700,535 | $220,025,785 | +$70,128,486 | $3.25 | 55 |
| 2022 Q1 | 44,505,507 | $89,003,268 | -$637,458 | $2.00 | 75 |
| 2021 Q4 | 47,273,566 | $148,445,513 | +$13,327,878 | $3.14 | 85 |
| 2021 Q3 | 37,428,616 | $183,549,240 | +$443,920 | $4.90 | 84 |
| 2021 Q2 | 37,041,724 | $246,690,021 | -$5,824,673 | $6.66 | 83 |
| 2021 Q1 | 38,279,773 | $214,770,368 | +$1,494,885 | $5.61 | 98 |
| 2020 Q4 | 36,082,417 | $283,967,815 | -$9,576,389 | $7.87 | 101 |
| 2020 Q3 | 37,117,432 | $315,925,313 | +$59,250,570 | $8.49 | 105 |
| 2020 Q2 | 29,421,942 | $306,284,769 | -$6,700,795 | $10.41 | 88 |
| 2020 Q1 | 30,100,828 | $282,072,986 | +$9,436,808 | $9.37 | 76 |
| 2019 Q4 | 29,216,613 | $234,164,963 | -$45,093,382 | $8.01 | 85 |
| 2019 Q3 | 30,879,604 | $633,952,522 | +$1,149,678 | $20.53 | 86 |
| 2019 Q2 | 30,198,680 | $787,916,581 | +$41,352,230 | $26.09 | 98 |
| 2019 Q1 | 29,379,379 | $1,141,323,791 | +$192,385,644 | $38.85 | 108 |
| 2018 Q4 | 24,392,678 | $1,025,469,934 | +$23,046,207 | $42.04 | 90 |
| 2018 Q3 | 23,803,148 | $1,190,156,500 | -$29,664,597 | $50.00 | 92 |
| 2018 Q2 | 24,464,983 | $935,783,108 | +$30,294,355 | $38.25 | 76 |
| 2018 Q1 | 23,663,816 | $948,860,012 | +$61,087,968 | $40.10 | 79 |
| 2017 Q4 | 22,225,342 | $780,113,100 | +$59,933,410 | $35.10 | 72 |
| 2017 Q3 | 20,492,602 | $445,796,252 | +$25,433,832 | $21.75 | 58 |
| 2017 Q2 | 19,316,233 | $359,305,882 | +$66,135,739 | $18.60 | 55 |
| 2017 Q1 | 15,709,867 | $431,755,770 | +$32,768,294 | $27.50 | 49 |
| 2016 Q4 | 14,817,269 | $388,165,611 | +$18,110,176 | $26.15 | 50 |
| 2016 Q3 | 14,060,800 | $456,548,375 | -$3,399,843 | $32.47 | 44 |
| 2016 Q2 | 14,199,612 | $293,778,139 | +$6,802,346 | $20.69 | 37 |
| 2016 Q1 | 14,000,592 | $192,282,000 | +$2,926,207 | $13.88 | 22 |
| 2015 Q4 | 13,788,757 | $218,725,000 | +$83,161,042 | $15.95 | 17 |