Brett P. Monia - Mar 11, 2025 Form 4 Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Role: Chief Executive Officer, Director
Signature: By: Patrick R. O'Neil, attorney-in-fact For: Brett P. Monia
Stock symbol: IONS
Transactions as of: Mar 11, 2025
Transactions value $: -$4,525
Form type: 4
Date filed: 3/13/2025, 04:45 PM
Previous filing: Mar 4, 2025
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	IONS	Common Stock	Sale	-$4.52K	-140	-0.08%	$32.32	181K	Mar 11, 2025	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id	Content
F1	Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024.