Brett P. Monia - Jul 30, 2025 Form 4 Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Signature
By: Patrick R. O'Neil, attorney-in-fact For: Brett P. Monia
Stock symbol
IONS
Transactions as of
Jul 30, 2025
Transactions value $
-$30,157
Form type
4
Date filed
8/1/2025, 04:06 PM
Previous filing
Jul 15, 2025
Next filing
Sep 3, 2025

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Monia Brett P Chief Executive Officer, Director 2855 GAZELLE COURT, CARLSBAD By: Patrick R. O'Neil, attorney-in-fact For: Brett P. Monia 2025-08-01 0001537529

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction IONS Common Stock Options Exercise $79.3K +2.43K +1.35% $32.60 182K Jul 30, 2025 Direct
transaction IONS Common Stock Sale -$109K -2.43K -1.33% $45.00 180K Jul 30, 2025 Direct F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction IONS Non-Qualified Stock Option (right to buy) Options Exercise $0 -2.43K -2.4% $0.00 99.1K Jul 30, 2025 Common Stock 2.43K $32.60 Direct
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024.