| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| O'NEIL PATRICK R. | EVP CLO & General Counsel | 2855 GAZELLE COURT, CARLSBAD | Patrick O'Neil | 2025-09-03 | 0001564926 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | IONS | Common Stock | Other | $9.17K | +331 | +0.58% | $27.71 | 57.1K | Aug 29, 2025 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | Reporting shares purchased under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on August 29, 2025. These shares may not be sold until March 2, 2026. |