| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| LOSCALZO JOSEPH | Director | 2855 GAZELLE COURT, CARLSBAD | By: Patrick R. O'Neil, attorney-in-fact For: Joseph Loscalzo | 04 Sep 2025 | 0001276128 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | IONS | Common Stock | Options Exercise | $391K | +16K | +44.04% | $24.42 | 52.3K | 03 Sep 2025 | Direct | |
| transaction | IONS | Common Stock | Sale | -$962K | -16K | -30.58% | $60.15 | 36.3K | 03 Sep 2025 | Direct | F1, F2 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | IONS | Non-Qualified Stock Option (right to buy) | Options Exercise | $0 | -16K | -100% | $0.00 | 0 | 03 Sep 2025 | Common Stock | 16K | $24.42 | Direct |
| Id | Content |
|---|---|
| F1 | Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024. |
| F2 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.00 to $60.57 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4. |