| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Arbuckle Stuart A | EVP, COO | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 2025-07-02 | 0001557290 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Common Stock | Tax liability | -$16.8M | -37.2K | -37.02% | $450.23 | 63.4K | Jul 1, 2025 | Direct | |
| holding | VRTX | Common Stock | 140 | Jul 1, 2025 | 401(k) |
Stuart A. Arbuckle is no longer subject to Section 16 filing requirements. Form 4 or Form 5 obligations may continue.