| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Kewalramani Reshma | CEO & President, Director | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 2025-08-07 | 0001735944 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Common Stock | Purchase | $1.67M | +4.29K | +4.05% | $389.08 | 110K | 06 Aug 2025 | Direct | F1, F2 |
| transaction | VRTX | Common Stock | Purchase | $2.23M | +5.71K | +5.18% | $389.95 | 116K | 06 Aug 2025 | Direct | F2, F3 |
| Id | Content |
|---|---|
| F1 | Open market purchases reported on this line occurred at a weighted average price of $389.08 (range $388.71 to $389.43). |
| F2 | Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares purchased at each separate price. |
| F3 | Open market purchases reported on this line occurred at a weighted average price of $389.95 (range $389.72 to $390.53). |