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        Signature
      
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        /s/ Darin Lippoldt, Attorney-in-Fact
      
      
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        Stock symbol
      
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        NBIX
      
      
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        Transactions as of
      
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        Jan 31, 2025
      
      
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        Transactions value $
      
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        -$184,599
      
      
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        Form type
      
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        4
      
      
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        Date filed
      
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        2/4/2025, 05:35 PM
      
 
     
   
 
  
    Transactions Table
  
  
    
      
        
          | Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes | 
      
      
          
            | transaction | NBIX | Common Stock | Options Exercise | $0 | +2.29K | +5.62% | $0.00 | 43.1K | Jan 31, 2025 | Direct |  | 
          
            | transaction | NBIX | Common Stock | Sale | -$185K | -1.21K | -2.8% | $152.94 | 41.9K | Jan 31, 2025 | Direct | F1, F2, F3 | 
      
    
   
  
    Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)
  
  
    
      
        
          | Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes | 
      
      
          
            | transaction | NBIX | Restricted Stock Unit | Options Exercise | $0 | -2.29K | -50% | $0.00 | 2.29K | Jan 31, 2025 | Common Stock | 2.29K |  | Direct | F4, F5 | 
      
    
   
  
    * An asterisk sign (*) next to the price indicates that the price is likely invalid.
  
  Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.
  Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).
  
    Explanation of Responses: