EcoR1 Capital, LLC - May 15, 2025 Form 4 Insider Report for Zymeworks Inc. (ZYME)

Role
Director, 10%+ Owner
Signature
/s/ Oleg Nodelman, Individually and as Manager of EcoR1 Capital, LLC
Stock symbol
ZYME
Transactions as of
May 15, 2025
Transactions value $
$635,586
Form type
4
Date filed
5/19/2025, 06:35 PM
Previous filing
May 16, 2025
Next filing
Jun 27, 2025
SEC
View on sec.gov

Reporting Owners (2)

Name Relationship Address Signature Signature date CIK
EcoR1 Capital, LLC Director, 10%+ Owner 357 TEHAMA STREET #3, SAN FRANCISCO /s/ Oleg Nodelman, Individually and as Manager of EcoR1 Capital, LLC 2025-05-19 0001587114
NODELMAN OLEG Director, 10%+ Owner 357 TEHAMA STREET #3, SAN FRANCISCO /s/ Oleg Nodelman, Individually and as Manager of EcoR1 Capital, LLC 2025-05-19 0001454385

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction ZYME Common Stock Purchase $566K +49.5K +0.28% $11.43 17.9M May 15, 2025 See Note F1, F2, F3
transaction ZYME Common Stock Purchase $69.7K +5.92K +0.03% $11.78 17.9M May 19, 2025 See Note F1, F4, F5
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.
F2 Qualified Fund purchased 46,405 of the shares purchased in this transaction.
F3 After this transaction, Qualified Fund held 16,758,589 shares of the Issuer's Common Stock.
F4 Qualified Fund purchased 5,550 of the shares purchased in this transaction.
F5 After this transaction, Qualified Fund held 16,764,139 shares of the Issuer's Common Stock.

Remarks:

Mr. Nodelman is a director of the Issuer. Scott Platshon, an employee of EcoR1, also serves as a director of the Issuer and was nominated for the board by EcoR1 and the Funds.