| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Smith Cynthia | Director | C/O SPERO THERAPEUTICS, INC., 675 MASSACHUSETTS AVENUE, 14TH FLOOR, CAMBRIDGE | /s/ Maegan Deare, Attorney-in-Fact for Cynthia Smith | 12 Jun 2025 | 0001609480 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | SPRO | Common Stock | Award | $0 | +20,000 | +36% | $0 | 75,000 | 12 Jun 2025 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest on June 12, 2026, subject to the Reporting Person's continued service through the applicable vesting date. |