Perceptive Advisors Llc - Aug 1, 2025 Form 4 Insider Report for Orchestra BioMed Holdings, Inc. (OBIO)

Role
10%+ Owner
Signature
/s/ Joseph Edelman - for Perceptive Advisors LLC, By: Joseph Edelman, its managing member
Stock symbol
OBIO
Transactions as of
Aug 1, 2025
Transactions value $
$6,049,850
Form type
4
Date filed
8/5/2025, 10:46 AM
Previous filing
Jun 13, 2025
SEC
View on sec.gov

Reporting Owners (3)

Name Relationship Address Signature Signature date CIK
PERCEPTIVE ADVISORS LLC 10%+ Owner 51 ASTOR PLACE, 10TH FLOOR, NEW YORK /s/ Joseph Edelman - for Perceptive Advisors LLC, By: Joseph Edelman, its managing member 2025-08-05 0001224962
PERCEPTIVE LIFE SCIENCES MASTER FUND LTD 10%+ Owner 51 ASTOR PLACE, 10TH FLOOR, NEW YORK /s/ Joseph Edelman - for Perceptive Life Sciences Master Fund, Ltd., By: Perceptive Advisors LLC, its investment manager, By: Joseph Edelman, its managing member 2025-08-05 0001249675
EDELMAN JOSEPH 10%+ Owner 51 ASTOR PLACE, 10TH FLOOR, NEW YORK /s/ Joseph Edelman 2025-08-05 0001164426

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction OBIO Common Stock Purchase $1.93M +700K +15.24% $2.75 5.29M Aug 1, 2025 See Footnote F1, F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction OBIO Pre-funded Warrants (right to buy) Purchase $4.12M +1.5M $2.75 1.5M Aug 1, 2025 Common Stock 1.5M $0.00 See footnote F2, F3, F4
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Perceptive Advisors Llc is no longer subject to Section 16 filing requirements. Form 4 or Form 5 obligations may continue.

Explanation of Responses:

Id Content
F1 Represents the purchase price for each share of Common Stock purchased by the Reporting Person in the Issuer's registered public offering that closed on August 1, 2025.
F2 The securities are directly held by Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of the Master Fund. Joseph Edelman ("Mr. Edelman") serves as the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of their indirect pecuniary interest therein, and this report shall not be deemed an admission that the Advisor or Mr. Edelman are beneficial owner of such securities for purposes of Section 16 or for any other purposes.
F3 The pre-funded warrants are immediately exercisable and will expire on the date they are exercised in full, subject to the Beneficial Ownership Limitation.
F4 Represents the purchase price for each pre-funded warrant purchased by the Reporting Person in the Issuer's registered public offering that closed on August 1, 2025.