Jacob A. Orville - Aug 5, 2025 Form 4 Insider Report for EXACT SCIENCES CORP (EXAS)

Role
EVP, GM, Screening
Signature
/s/ Jacob A. Orville by Mark Busch, attorney-in-fact
Stock symbol
EXAS
Transactions as of
Aug 5, 2025
Transactions value $
-$117,777
Form type
4
Date filed
8/7/2025, 05:30 PM
Previous filing
Mar 4, 2025
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
ORVILLE JACOB A EVP, GM, Screening C/O EXACT SCIENCES CORP., 5505 ENDEAVOR LANE, MADISON /s/ Jacob A. Orville by Mark Busch, attorney-in-fact 2025-08-07 0001263312

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction EXAS Common Stock Options Exercise $0 +5.35K +21.06% $0.00 30.8K Aug 5, 2025 Direct F1
transaction EXAS Common Stock Tax liability -$118K -2.52K -8.18% $46.83 28.2K Aug 5, 2025 Direct F2, F3
holding EXAS Common Stock 1.49K Aug 5, 2025 Held in 401(k) Plan

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction EXAS Restricted Stock Units Options Exercise $0 -5.35K -25% $0.00 16.1K Aug 5, 2025 Common Stock 5.35K Direct F4, F5
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 Represents shares of common stock received upon vesting of a restricted stock unit award.
F2 Represents shares of Common Stock retained by Exact Sciences Corporation for tax withholding purposes in connection with the net-settlement on the issuance of shares of Common Stock in respect to the vesting of certain restricted stock units.
F3 In addition to the shares of Common Stock reported on this Form 4, which total 29,727 shares, Mr. Orville also holds, in the aggregate, an additional 79,661 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock.
F4 Each restricted stock unit represents a contingent right to receive one share of common stock.
F5 Represents a restricted stock unit award granted on August 5, 2024 that partially vested on August 5, 2025. The restricted stock units vest in four equal annual installments.

Remarks:

Exhibit 24.1: Power of Attorney