| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Klein Uwe | SVP, Biological Sciences | C/O SEPTERNA, INC., 250 EAST GRAND AVENUE, SOUTH SAN FRANCISCO | /s/ Ran Xiao, Attorney-in-Fact | 11 Aug 2025 | 0002040350 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | SEPN | Stock Option (Right to Buy) | Award | $0 | +30,000 | $0.000000 | 30,000 | 07 Aug 2025 | Common Stock | 30,000 | $11.70 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date. |