Elizabeth Bhatt - Aug 7, 2025 Form 4 Insider Report for Septerna, Inc. (SEPN)

Role: President and COO
Signature: /s/ Ran Xiao, Attorney-in-Fact
Stock symbol: SEPN
Transactions as of: Aug 7, 2025
Transactions value $: $0
Form type: 4
Date filed: 8/11/2025, 07:09 PM
Previous filing: Oct 24, 2024
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Bhatt Elizabeth	President and COO	C/O SEPTERNA, INC., 250 EAST GRAND AVENUE, SOUTH SAN FRANCISCO	/s/ Ran Xiao, Attorney-in-Fact	2025-08-11	0001748622

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	SEPN	Stock Option (Right to Buy)	Award	$0	+95K		$0.00	95K	Aug 7, 2025	Common Stock	95K	$11.70	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.