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        Signature
      
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        /s/ Todd D.C. Anderman, as Attorney-in-Fact for Adrienne L. Graves
      
      
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        Stock symbol
      
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        ISEE
      
      
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        Transactions as of
      
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        Jul 11, 2023
      
      
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        Transactions value $
      
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        $0
      
      
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        Form type
      
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        4
      
      
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        Date filed
      
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        7/13/2023, 02:00 PM
      
 
     
   
 
  
    Transactions Table
  
  
    
      
        
          | Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes | 
      
      
          
            | transaction | ISEE | Common Stock | Disposed to Issuer |  | -22.1K | -100% |  | 0 | Jul 11, 2023 | Direct | F1 | 
      
    
   
  
    Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)
  
  
    
      
        
          | Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes | 
      
      
          
            | transaction | ISEE | Restricted Stock Units | Disposed to Issuer |  | -7.5K | -100% |  | 0 | Jul 11, 2023 | Common Stock | 7.5K |  | Direct | F2, F3 | 
          
            | transaction | ISEE | Stock Option (Right to Buy) | Disposed to Issuer |  | -32K | -100% |  | 0 | Jul 11, 2023 | Common Stock | 32K | $1.45 | Direct | F4 | 
          
            | transaction | ISEE | Stock Option (Right to Buy) | Disposed to Issuer |  | -16K | -100% |  | 0 | Jul 11, 2023 | Common Stock | 16K | $1.39 | Direct | F4 | 
          
            | transaction | ISEE | Stock Option (Right to Buy) | Disposed to Issuer |  | -16K | -100% |  | 0 | Jul 11, 2023 | Common Stock | 16K | $4.14 | Direct | F4 | 
          
            | transaction | ISEE | Stock Option (Right to Buy) | Disposed to Issuer |  | -15.5K | -100% |  | 0 | Jul 11, 2023 | Common Stock | 15.5K | $6.82 | Direct | F4 | 
          
            | transaction | ISEE | Stock Option (Right to Buy) | Disposed to Issuer |  | -23.2K | -100% |  | 0 | Jul 11, 2023 | Common Stock | 23.2K | $9.94 | Direct | F4 | 
      
    
   
  
    * An asterisk sign (*) next to the price indicates that the price is likely invalid.
  
  Adrienne L. Graves is no longer subject to Section 16 filing requirements. Form 4 or Form 5 obligations may continue.
  
    Explanation of Responses: