Konstantinos Xynos - Nov 17, 2025 Form 4 Insider Report for Replimune Group, Inc. (REPL)

Role: Chief Medical Officer
Signature: /s/ Shawn Glidden, attorney-in-fact
Stock symbol: REPL
Transactions as of: Nov 17, 2025
Transactions value $: -$65,957
Form type: 4
Date filed: 11/19/2025, 04:30 PM
Previous filing: May 22, 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Xynos Konstantinos	Chief Medical Officer	C/O REPLIMUNE GROUP, INC., 500 UNICORN PARK DRIVE, SUITE 303, WOBURN	/s/ Shawn Glidden, attorney-in-fact	2025-11-19	0001956241

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	REPL	Common Stock	Sale	-$66K	-7.25K	-4.93%	$9.10	140K	Nov 17, 2025	Direct	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents shares of the Issuer's common stock (the "Shares") sold to cover tax withholding obligations in connection with the partial vesting of the Reporting Person's Restricted Stock Units ("RSU"). The transaction reported herein was made in accordance with the irrevocable "sell to cover" provision set forth in the award agreements under which the RSUs were granted and does not represent a discretionary sale by the Reporting Person.
F2	The price reported reflects a weighted average price of the Shares calculated by the broker executing the sell-to-cover transactions. The Shares were sold as part of a block trade in multiple transactions at prices ranging from $8.88 to $9.26 per Share. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the Securities Exchange Commission staff, upon request, information regarding the number of Shares sold at each price within the range.

Content

Represents shares of the Issuer's common stock (the "Shares") sold to cover tax withholding obligations in connection with the partial vesting of the Reporting Person's Restricted Stock Units ("RSU"). The transaction reported herein was made in accordance with the irrevocable "sell to cover" provision set forth in the award agreements under which the RSUs were granted and does not represent a discretionary sale by the Reporting Person.

The price reported reflects a weighted average price of the Shares calculated by the broker executing the sell-to-cover transactions. The Shares were sold as part of a block trade in multiple transactions at prices ranging from $8.88 to $9.26 per Share. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the Securities Exchange Commission staff, upon request, information regarding the number of Shares sold at each price within the range.