Everett Rand Sutherland - 02 Jan 2026 Form 4 Insider Report for Upstream Bio, Inc. (UPB)

Role
Chief Executive Officer, Director
Signature
/s/ Allison Ambrose, Attorney-in-Fact
Issuer symbol
UPB
Transactions as of
02 Jan 2026
Net transactions value
$0
Form type
4
Filing time
06 Jan 2026, 17:15:02 UTC
Previous filing
30 Jun 2025
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Sutherland Everett Rand Chief Executive Officer, Director UPSTREAM BIO, INC., 890 WINTER STREET, SUITE 200, WALTHAM /s/ Allison Ambrose, Attorney-in-Fact 06 Jan 2026 0001852880

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction UPB Common Stock Award $0 +75,000 $0.000000 75,000 02 Jan 2026 Direct F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction UPB Stock Option (Right to Buy) Award $0 +225,000 $0.000000 225,000 02 Jan 2026 Common Stock 225,000 $27.07 Direct F2
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 Represents restricted stock units ("RSUs") granted pursuant to the Issuer's 2024 Stock Option and Incentive Plan. Each RSU represents the contingent right to receive one share of the Issuer's Common Stock upon vesting. The RSUs shall vest in sixteen equal quarterly installments following January 1, 2026, subject to the Reporting Person's continued service on each such vesting date.
F2 The shares underlying this option shall vest in forty-eight equal monthly installments following January 1, 2026, subject to the Reporting Person's continued service on each such vesting date.