James E. Flynn - Nov 24, 2025 Form 4 Insider Report for Nuvalent, Inc. (NUVL)

Signature
/s/ Jonathan Isler, Attorney-in-Fact
Stock symbol
NUVL
Transactions as of
Nov 24, 2025
Transactions value $
-$70,874,975
Form type
4
Date filed
11/24/2025, 08:00 PM
Previous filing
Aug 4, 2025

Reporting Owners (8)

Name Relationship Address Signature Signature date CIK
Flynn James E Director, Director by Deputization, 10%+ Owner 345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK /s/ Jonathan Isler, Attorney-in-Fact 2025-11-24 0001352546
DEERFIELD MANAGEMENT COMPANY, L.P. Director, Director by Deputization, 10%+ Owner 345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK /s/ Jonathan Isler, Attorney-in-Fact 2025-11-24 0001009258
Deerfield Mgmt HIF, L.P. Director, Director by Deputization, 10%+ Owner 345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK /s/ Jonathan Isler, Attorney-in-Fact 2025-11-24 0001665736
Deerfield Healthcare Innovations Fund, L.P. Director, Director by Deputization, 10%+ Owner 345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK /s/ Jonathan Isler, Attorney-in-Fact 2025-11-24 0001646981
DEERFIELD PARTNERS, L.P. Director, Director by Deputization, 10%+ Owner 345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK /s/ Jonathan Isler, Attorney-in-Fact 2025-11-24 0001301041
Deerfield Mgmt L.P. Director, Director by Deputization, 10%+ Owner 345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK /s/ Jonathan Isler, Attorney-in-Fact 2025-11-24 0001010823
Deerfield Mgmt IV, L.P. Director, Director by Deputization, 10%+ Owner 345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK /s/ Jonathan Isler, Attorney-in-Fact 2025-11-24 0001713467
Deerfield Private Design Fund IV, L.P. Director, Director by Deputization, 10%+ Owner 345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK /s/ Jonathan Isler, Attorney-in-Fact 2025-11-24 0001680307

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction NUVL Class A Common Stock Sale -$35.4M -371K -4.28% $95.45 8.3M Nov 24, 2025 Through Deerfield Private Design Fund IV, L.P. F1, F2, F3
transaction NUVL Class A Common Stock Sale -$35.4M -371K -4.28% $95.45 8.3M Nov 24, 2025 Through Deerfield Healthcare Innovations Fund, L.P. F1, F2, F3
holding NUVL Class A Common Stock 650K Nov 24, 2025 Through Deerfield Partners, L.P. F2, F3
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 The shares of Class A Common Stock were sold to underwriters pursuant to the exercise of the underwriters' option to purchase shares of Class A Common Stock from Deerfield Private Design Fund IV, L.P. and Deerfield Healthcare Innovations Fund, L.P., at a price per share of $95.445, to cover over-allotments in an underwritten public offering. The shares were sold to the public in the offering at a price of $101.00 per share.
F2 This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the "Reporting Persons"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. ("Deerfield Partners"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. ("Fund IV"). Deerfield Mgmt HIF, L.P. is the general partner of Deerfield Healthcare Innovations Fund, L.P. (collectively with Deerfield Partners and Fund IV, the "Funds"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt HIF, L.P. and Deerfield Management Company, L.P.
F3 In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise.

Remarks:

Each of Cameron Wheeler, a partner in Deerfield Management, and Joseph Pearlberg, an employee of Deerfield Management, serves as a director of the Issuer. Jonathan Isler, Attorney-in-Fact: Power of Attorney, which is hereby incorporated by reference to Exhibit 24 to a Form 3 with regard to BiomX Inc. filed with the Securities and Exchange Commission on March 19, 2024 by Deerfield Private Design Fund V, L.P., Deerfield Healthcare Innovations Fund II, L.P., Deerfield Mgmt V, L.P., Deerfield Mgmt HIF II, L.P., Deerfield Management Company, L.P. and James E. Flynn.