- 
        Signature
      
 
      - 
        /s/ Darin Lippoldt, Attorney-in-Fact
      
 
    
    
      
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        Stock symbol
      
 
      - 
        NBIX
      
 
    
    
      
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        Transactions as of
      
 
      - 
        Apr 19, 2023
      
 
    
    
      
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        Transactions value $
      
 
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        -$728,605
      
 
    
    
      
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        Form type
      
 
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        4
      
 
    
    
      
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        Date filed
      
 
      - 
        4/21/2023, 06:58 PM
      
 
    
    
    
    
   
     
   
 
  
    Transactions Table
  
  
    
      
        
          | Type | 
          Sym | 
          Class | 
          Transaction | 
          Value $ | 
          Shares | 
          Change % | 
          * Price $ | 
          Shares After | 
          Date | 
          Ownership | 
          Footnotes | 
        
      
      
          
            | transaction | 
            NBIX | 
            Common Stock | 
            Options Exercise | 
            $20.5K | 
            +1.61K | 
            +4.73% | 
            $12.71* | 
            35.6K | 
            Apr 19, 2023 | 
            Direct | 
             | 
          
          
            | transaction | 
            NBIX | 
            Common Stock | 
            Sale | 
            -$94.8K | 
            -903 | 
            -2.53% | 
            $105.00 | 
            34.7K | 
            Apr 19, 2023 | 
            Direct | 
            F1, F2 | 
          
          
            | transaction | 
            NBIX | 
            Common Stock | 
            Options Exercise | 
            $137K | 
            +10.8K | 
            +31% | 
            $12.71* | 
            45.5K | 
            Apr 21, 2023 | 
            Direct | 
             | 
          
          
            | transaction | 
            NBIX | 
            Common Stock | 
            Sale | 
            -$634K | 
            -6.03K | 
            -13.26% | 
            $105.04 | 
            39.5K | 
            Apr 21, 2023 | 
            Direct | 
            F1, F3, F4 | 
          
      
    
   
  
    Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)
  
  
    
      
        
          | Type | 
          Sym | 
          Class | 
          Transaction | 
          Value $ | 
          Shares | 
          Change % | 
          * Price $ | 
          Shares After | 
          Date | 
          Underlying Class | 
          Amount | 
          Exercise Price | 
          Ownership | 
          Footnotes | 
        
      
      
          
            | transaction | 
            NBIX | 
            Non-Qualified Stock Option | 
            Options Exercise | 
            -$20.5K | 
            -1.61K | 
            -8.05% | 
            $12.71* | 
            18.4K | 
            Apr 19, 2023 | 
            Common Stock | 
            1.61K | 
            $12.71 | 
            Direct | 
            F5 | 
          
          
            | transaction | 
            NBIX | 
            Non-Qualified Stock Option | 
            Options Exercise | 
            -$137K | 
            -10.8K | 
            -58.54% | 
            $12.71* | 
            7.63K | 
            Apr 21, 2023 | 
            Common Stock | 
            10.8K | 
            $12.71 | 
            Direct | 
            F5 | 
          
      
    
   
  
    * An asterisk sign (*) next to the price indicates that the price is likely invalid.
  
  Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.
  Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).
  
    Explanation of Responses: