Adam Laponis - 08 Oct 2025 Form 4 Insider Report for Twist Bioscience Corp (TWST)

Role: Chief Financial Officer
Signature: /s/ Kendra Fox, as Attorney-in-Fact for Adam Laponis
Issuer symbol: TWST
Transactions as of: 08 Oct 2025
Net transactions value: -$176,315
Form type: 4
Filing time: 10 Oct 2025, 16:05:09 UTC
Previous filing: 08 Oct 2025
Next filing: 30 Oct 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Laponis Adam	Chief Financial Officer	C/O TWIST BIOSCIENCE CORPORATION, 681 GATEWAY BLVD, SOUTH SAN FRANCISCO	/s/ Kendra Fox, as Attorney-in-Fact for Adam Laponis	10 Oct 2025	0001827198

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	TWST	Common Stock	Sale	$93,450	-3,000	-3.1%	$31.15	94,042	08 Oct 2025	Direct	F1
transaction	TWST	Common Stock	Sale	$82,865	-2,517	-2.7%	$32.92	91,525	09 Oct 2025	Direct	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id	Content
F1	The transaction reported on this Form 4 is effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person on May 8, 2025.
F2	Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of Restricted Stock Units. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.

Content

The transaction reported on this Form 4 is effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person on May 8, 2025.

Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of Restricted Stock Units. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.