DANIEL K. SPIEGELMAN - 22 Sep 2025 Form 4 Insider Report for Maze Therapeutics, Inc. (MAZE)

Role: Director
Signature: /s/ Courtney Phillips, as attorney-in-fact
Issuer symbol: MAZE
Transactions as of: 22 Sep 2025
Net transactions value: $0
Form type: 4
Filing time: 24 Sep 2025, 16:21:04 UTC
Previous filing: 24 Jul 2025
Next filing: 15 Dec 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
SPIEGELMAN DANIEL K	Director	C/O MAZE THERAPEUTICS, INC., 171 OYSTER POINT BOULEVARD, SUITE 300, SOUTH SAN FRANCISCO	/s/ Courtney Phillips, as attorney-in-fact	24 Sep 2025	0001238403

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	MAZE	Stock Option (Right to Buy)	Award	$0	+18,000		$0.000000	18,000	22 Sep 2025	Common Stock	18,000	$23.67	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The option shall vest as to 1/9 of the total award monthly with the first tranche vesting on October 1, 2025, subject to the reporting person's continued service to the Issuer on the applicable vesting date.