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        Signature
      
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        /s/ Michele Farmer, Attorney-in-fact
      
      
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        Stock symbol
      
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        PACB
      
      
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        Transactions as of
      
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        Jun 4, 2025
      
      
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        Transactions value $
      
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        $0
      
      
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        Form type
      
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        4
      
      
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        Date filed
      
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        6/6/2025, 04:10 PM
      
 
     
   
 
  
    Reporting Owners (1)
  
  
    
      
        
          | Name | Relationship | Address | Signature | Signature date | CIK | 
      
      
          
            | LIVINGSTON RANDALL S | Director | PACIFIC BIOSCIENCES OF CALIFORNIA, INC., 1305 O'BRIEN DRIVE, MENLO PARK | /s/ Michele Farmer, Attorney-in-fact | 2025-06-06 | 0001235118 | 
      
    
   
  
    Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)
  
  
    
      
        
          | Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes | 
      
      
          
            | transaction | PACB | Stock Option (right to buy) | Award | $0 | +65K |  | $0.00 | 65K | Jun 4, 2025 | Common Stock | 65K | $1.03 | Direct | F1 | 
      
    
   
  
    * An asterisk sign (*) next to the price indicates that the price is likely invalid.
  
  
    Explanation of Responses:
  
  
  
    Remarks:
  
  Exhibit List: Exhibit 24 - Power Of Attorney