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        Signature
      
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        /s/ Eric Trachtenberg, Attorney-in-Fact
      
      
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        Stock symbol
      
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        KALA
      
      
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        Transactions as of
      
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        Mar 14, 2023
      
      
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        Transactions value $
      
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        $0
      
      
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        Form type
      
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        4
      
      
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        Date filed
      
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        3/15/2023, 08:00 PM
      
 
     
   
 
  
    Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)
  
  
    
      
        
          | Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes | 
      
      
          
            | transaction | KALA | Stock Option (Right to Buy) | Award | $0 | +576 |  | $0.00 | 576 | Mar 14, 2023 | Common Stock | 576 | $68.50 | Direct | F1, F2 | 
      
    
   
  
    * An asterisk sign (*) next to the price indicates that the price is likely invalid.
  
  
    Explanation of Responses:
  
  
  
    Remarks:
  
  President and Chief Operating Officer