| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | Director, 10%+ Owner | 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, Manager of RA Capital Management, L.P. | 2025-05-14 | 0001346824 |
| RA Capital Healthcare Fund LP | Director, 10%+ Owner | 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, Manager of RA Capital Healthcare Fund GP, LLC, the General Partner of RA Capital Healthcare Fund, L.P. | 2025-05-14 | 0001315082 |
| RA Capital Nexus Fund II, L.P. | Director, 10%+ Owner | 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, Manager of RA Capital Nexus Fund II GP, LLC, the General Partner of RA Capital Nexus Fund II, L.P. | 2025-05-14 | 0001825376 |
| Kolchinsky Peter | Director, 10%+ Owner | C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, individually | 2025-05-14 | 0001384859 |
| Shah Rajeev M. | Director, 10%+ Owner | C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Rajeev Shah, individually | 2025-05-14 | 0001619841 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | HOWL | Common Stock | Purchase | $276K | +321K | +5.63% | $0.86 | 6.02M | May 12, 2025 | See footnotes | F1, F2, F3 |
| transaction | HOWL | Common Stock | Purchase | $51.9K | +53K | +0.88% | $0.98 | 6.07M | May 13, 2025 | See footnotes | F2, F3, F4 |
| transaction | HOWL | Common Stock | Purchase | $159K | +163K | +2.68% | $0.98 | 6.24M | May 14, 2025 | See footnotes | F2, F3, F5 |
| holding | HOWL | Common Stock | 444K | May 12, 2025 | See footnotes | F3, F6 |
| Id | Content |
|---|---|
| F1 | The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.82 to $0.89 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. |
| F2 | Held directly by RA Capital Healthcare Fund, L.P. (the "Fund"). |
| F3 | RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund") and RA Capital Nexus Fund II, L.P. (the "Nexus Fund II"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. |
| F4 | The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.96 to $0.99 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. |
| F5 | The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.96 to $0.99 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. |
| F6 | Held directly by Nexus Fund II. |
Dr. Derek DiRocco, a Partner of the Adviser, serves on the Issuer's board of directors.