| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | Director, 10%+ Owner | 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, Manager of RA Capital Management, L.P. | 2025-06-26 | 0001346824 |
| RA Capital Healthcare Fund LP | Director, 10%+ Owner | 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, Manager of RA Capital Healthcare Fund GP, LLC, the General Partner of RA Capital Healthcare Fund, L.P. | 2025-06-26 | 0001315082 |
| RA Capital Nexus Fund, L.P. | Director | 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, Manager of RA Capital Nexus Fund GP, LLC, the General Partner of RA Capital Nexus Fund, L.P. | 2025-06-26 | 0001780117 |
| RA Capital Nexus Fund III, L.P. | Director | 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, Manager of RA Capital Nexus Fund III GP, LLC, the General Partner of RA Capital Nexus Fund III, L.P. | 2025-06-26 | 0001883840 |
| Kolchinsky Peter | Director, 10%+ Owner | C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, individually | 2025-06-26 | 0001384859 |
| Shah Rajeev M. | Director, 10%+ Owner | C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Rajeev Shah, individually | 2025-06-26 | 0001619841 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ARTV | Director Stock Option (Right to Buy) | Award | $0 | +13.8K | $0.00 | 13.8K | Jun 24, 2025 | Common Stock | 13.8K | $1.61 | See Footnotes | F1, F2, F3 |
| Id | Content |
|---|---|
| F1 | Represents the grant of a stock option to Laura Stoppel pursuant to the Issuer's non-employee director compensation policy. The shares subject to the option will vest on the earlier of June 24, 2026 or the date of the Issuer's 2026 annual stockholder meeting, subject to Dr. Stoppel's continuous service as a director through such vesting date. |
| F2 | RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund, L.P. (the "Nexus Fund"), RA Capital Nexus Fund III, L.P. (the "Nexus Fund III"), and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, the Fund, the Nexus Fund, the Nexus Fund III, Dr. Kolchinsky and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of its or his pecuniary interest therein. |
| F3 | Laura Stoppel is a Partner of the Adviser who serves on the Issuer's board of directors. Under Dr. Stoppel's arrangement with the Adviser, Dr. Stoppel holds the option for the benefit of the Fund, the Nexus Fund, the Nexus Fund III and the Account. Dr. Stoppel is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund, the Nexus Fund, the Nexus Fund III and the Account to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock. |
Laura Stoppel, a Partner of the Adviser, serves on the Issuer's board of directors