Bali Muralidhar - Jul 22, 2025 Form 4 Insider Report for SPRUCE BIOSCIENCES, INC. (SPRB)

Role: Director
Signature: /s/ Samir Gharib, Attorney-in-Fact
Stock symbol: SPRB
Transactions as of: Jul 22, 2025
Transactions value $: $0
Form type: 4
Date filed: 7/24/2025, 07:30 PM
Previous filing: May 24, 2024
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Muralidhar Bali	Director	C/O SPRUCE BIOSCIENCES, INC., 611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO	/s/ Samir Gharib, Attorney-in-Fact	2025-07-24	0001784138

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	SPRB	Stock Option (Right to Buy)	Award	$0	+30K		$0.00	30K	Jul 22, 2025	Common Stock	30K	$0.12	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2026 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).