| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Gregoire Sylvie | Director, 10%+ Owner | 20 PARK PLAZA, SUITE 424, BOSTON | /s/ William R. Elder, attorney-in-fact for the Reporting Person | 2025-11-13 | 0001335822 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | CRVO | Common Stock | Purchase | $40.8K | +5.55K | +0.38% | $7.35 | 1.47M | Nov 12, 2025 | Direct | F1, F2 |
| Id | Content |
|---|---|
| F1 | Shares purchased in open-market transactions. |
| F2 | Shares held jointly by the Reporting Person and her spouse, Dr. John Alam, M.D., the Issuer's President & Chief Executive Officer and a member of the Issuer's Board of Directors. |