| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Smith Cynthia | Director | C/O AGIOS PHARMACEUTICALS, INC., 88 SIDNEY STREET, CAMBRIDGE | /s/ William Cook, as attorney-in-fact for Cynthia Smith | 13 Aug 2025 | 0001609480 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | AGIO | Common stock | Options Exercise | $0 | +2,302 | +23% | $0 | 12,414 | 11 Aug 2025 | Direct |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | AGIO | Restricted stock units | Options Exercise | $0 | -2,302 | -100% | $0 | 0 | 11 Aug 2025 | Common stock | 2,302 | Direct | F1, F2 |
| Id | Content |
|---|---|
| F1 | Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. |
| F2 | The restricted stock units were granted on August 11, 2022. Beginning on August 11, 2023, the shares underlying the restricted stock units will vest in three equal annual installments. |