Mario Alberto Accardi - Nov 1, 2025 Form 4 Insider Report for Centessa Pharmaceuticals plc (CNTA)

Role: President, Orexin Program
Signature: /s/ Raphael Deferiere, attorney-in-fact
Stock symbol: CNTA
Transactions as of: Nov 1, 2025
Transactions value $: -$14,766
Form type: 4
Date filed: 11/3/2025, 04:14 PM
Previous filing: Oct 27, 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Accardi Mario Alberto	President, Orexin Program	C/O CENTESSA PHARMACEUTICALS PLC, 3RD FL., 1 ASHLEY RD, ALTRINCHAM, CHESHIRE, UNITED KINGDOM	/s/ Raphael Deferiere, attorney-in-fact	2025-11-03	0002074392

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	CNTA	Ordinary Shares	Tax liability	-$14.8K	-593	-0.31%	$24.90	194K	Nov 1, 2025	Direct	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.
F2	Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of restricted share units.